This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Brand Names
Activon Arthritis, Bengay, Calazime Skin Protectant, Calmodrox, Calmoseptine Ointment, Capzasin Quick Relief, Chloraseptic Sore Throat, Chloraseptic Sore Throat + Cough, Delsym Cough Plus Soothing Action, Delsym Cough Relief Plus Soothing Action, Dendracin Neurodendraxcin, Fast Freeze, Flexall Ultra Plus, Gold Bond Maximum Relief, Icy Hot Arthritis, Ivy-dry Cream, Lidopro, Lidothol, Listerine Antiseptic, Max-freeze, Medi-derm, Medi-derm With Lidocaine, Medicaine Sting and Bite, Medrox, Men-phor, Orasep Reformulated Dec 2013, Ortho-nesic, Rematex, Salonpas Gel-patch, Salonpas Pain Relieving Patch, Sarna Sensitive, Sucrets, Tiger Balm, Vaporex, Vicks Vaporub, Xoten-C
Generic Name
Menthol
DrugBank Accession Number
DB14123
Background

Not Available

Type
Small Molecule
Groups
Approved
Structure
Weight
Average: 156.269
Monoisotopic: 156.151415264
Chemical Formula
C10H20O
Synonyms
  • (+-)-Menthol
  • (1R,2S,5R)-Menthol
  • DL-menthol
  • Hexahydrothymol
  • Menthol natural
  • Menthol racemic
  • Menthol racemique
  • p-Menthan-3-ol
  • Racementhol
  • Racementholum
  • Racementol
External IDs
  • 89-78-1
  • FEMA NO. 2665

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
UTransient receptor potential cation channel subfamily M member 8
agonist
Humans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Our datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.
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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
0 Degrees Pain RelievingGel5 g/100mLTopicalRlabs, Llc2016-04-012016-08-11US flag
2 in 1 Relief Value Pack0.05 g/1gTopicalRB Health (US) LLC2020-09-302024-12-31US flag
4JointzCream1.5 g/100gTopicalArp(usa) Pty Ltd2017-01-31Not applicableUS flag
4RLF Topical AnalgesicCream0.1 g/1mLTopicalRinati Skin, LLC2021-08-23Not applicableUS flag
A.C.C Fresh and Cooling Scalp MistLiquid0.3 g/100mLTopicalNature4 Co., Ltd.2019-10-01Not applicableUS flag
A.C.C Fresh and Cooling Scalp MistLiquid0.3 g/100mLTopicalNature4 Co., Ltd.2017-07-262019-12-01US flag
Abejas y Viboras Brand Roll-OnGel5 mg/100mLTopicalMENPER DISTRIBUTORS INC.2021-03-01Not applicableUS flag
AbsorbineGel100 mg/1gTopicalW. F. Young, Inc.2011-01-102013-01-31US flag
Absorbine BACK Therapeutic Pain ReliefPatch5 g/100gTopicalTeh Seng Pharmaceutical Mfg. Co., Ltd.2013-10-102021-04-30US flag
Absorbine JrCream2.5 g/100gTopicalW. F. Young, Inc.2012-04-302015-06-30US flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
1st Medxpatch With Lidocaine 4%Menthol (5 g/1) + Capsaicin (0.025 g/1) + Lidocaine (4 g/1) + Methyl salicylate (20 g/1)PatchTopical1ST MEDX LLC2018-03-15Not applicableUS flag
1st RELIEF TOPICALMenthol (10 mg/1mL) + Lidocaine (40 mg/1mL)SprayTopical1st Class Pharmaceuticals, Inc.2014-12-02Not applicableUS flag
24 Alopecia ReliefshampooMenthol (0.3 g/100mL) + Panthenol (0.2 g/100mL) + Salicylic acid (0.25 g/100mL)ShampooTopicalDERMA CENTRIC INC2020-08-08Not applicableUS flag
2x Med LiqMenthol (0.1 mg/100mL) + Benzocaine (20 mg/100mL)LiquidOralLornamead2021-09-01Not applicableUS flag
2x Med LiqMenthol (0.1 mg/100mL) + Benzocaine (20 mg/100mL)LiquidOralCSR Cosmetic Solutions2021-09-01Not applicableUS flag
365 Whole Foods Market Anticavity/Antigingivitis MouthwashMenthol (0.42 mg/1mL) + Eucalyptol (0.92 mg/1mL) + Methyl salicylate (0.6 mg/1mL) + Sodium fluoride (0.1 mg/1mL) + Thymol (0.64 mg/1mL)MouthwashDentalWhole Foods Market, Inc.2022-01-31Not applicableUS flag
365 Whole Foods Market Antigingivitis MouthwashMenthol (0.42 mg/1mL) + Eucalyptol (0.92 mg/1mL) + Methyl salicylate (0.6 mg/1mL) + Thymol (0.64 mg/1mL)MouthwashDentalWhole Foods Market, Inc.2022-01-31Not applicableUS flag
3x Medicated Mouth Sore GelMenthol (0.1 g/100g) + Benzocaine (20 g/100g) + Zinc chloride (0.15 g/100g)GelOralHEB2020-06-02Not applicableUS flag
3x Medicated Mouth Sore GelMenthol (0.1 g/100g) + Benzocaine (20 g/100g) + Zinc chloride (0.15 g/100g)GelOralCVS2020-06-05Not applicableUS flag
3X Medicated Mouth Sore GelMenthol (0.1 g/100g) + Benzocaine (20 g/100g) + Zinc chloride (0.15 g/100g)GelOralRite Aid2020-06-05Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
1st Medxpatch With Lidocaine 4%-rxMenthol (5 g/1) + Capsaicin (0.0375 g/1) + Lidocaine (4 g/1) + Methyl salicylate (20 g/1)PatchTopical1ST MEDX LLC2018-03-15Not applicableUS flag
1st Medxpatch With Lidocaine 4%-rxMenthol (5 1/1) + Capsaicin (0.0375 1/1) + Lidocaine (4 1/1) + Methyl salicylate (20 1/1)PatchTopicalDirect Rx2020-10-14Not applicableUS flag
24 Alopecia ReliefshampooMenthol (0.3 g/100mL) + Panthenol (0.2 g/100mL) + Salicylic acid (0.25 g/100mL)ShampooTopicalDERMA CENTRIC INC2020-08-08Not applicableUS flag
4125 First Aid KitMenthol (0.33 g/100g) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOphthalmic; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4204 First Aid KitMenthol (7 mg/1) + Acetaminophen (325 mg/1) + Benzalkonium chloride (0.13 g/100mL) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL)KitOphthalmic; Oral; TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4210 First Aid KitMenthol (7 mg/1) + Acetaminophen (325 mg/1) + Benzalkonium chloride (0.13 g/100mL) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL)KitOphthalmic; Oral; TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4221 First Aid KitMenthol (0.33 g/100g) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4230 First Aid KitMenthol (0.33 g/100g) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4232 First Aid KitMenthol (0.33 g/100g) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag
4240 First Aid KitMenthol (0.33 g/100g) + Acetaminophen (325 mg/1) + Acetylsalicylic acid (325 mg/1) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Calcium carbonate (420 mg/1) + Isopropyl alcohol (0.7 mL/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)KitOphthalmic; Oral; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc2018-10-18Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
L7T10EIP3A
CAS number
1490-04-6
InChI Key
NOOLISFMXDJSKH-UHFFFAOYSA-N
InChI
InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3
IUPAC Name
5-methyl-2-(propan-2-yl)cyclohexan-1-ol
SMILES
CC(C)C1CCC(C)CC1O

References

General References
Not Available
Human Metabolome Database
HMDB0035765
ChemSpider
1216
BindingDB
248162
RxNav
1430390
ChEBI
25187
ChEMBL
CHEMBL256087
Wikipedia
Menthol

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Active Not RecruitingTreatmentChronic Lower Back Pain (CLBP)1
4CompletedPreventionMenstrual Cycle Abnormal1
4CompletedTreatmentCervical Ripening / Induction of Labour1
4CompletedTreatmentChronic Lower Back Pain (CLBP)1
4CompletedTreatmentDiaper Dermatitis1
4CompletedTreatmentInfertility1
4CompletedTreatmentSub-acute Back Pain1
4RecruitingBasic ScienceLeg Veins1
4RecruitingTreatmentCentral Nervous System Embryonal Tumors / Medulloblastomas1
4RecruitingTreatmentEmbryo Transfer1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
GelOral
KitOphthalmic; Oral; Topical
KitOphthalmic; Oral; Respiratory (inhalation); Topical
KitOphthalmic; Respiratory (inhalation); Topical
KitOphthalmic; Topical
CreamTopical0.1 g/1mL
CreamOral
LiquidTopical0.3 g/100mL
GelTopical5 mg/100mL
GelTopical100 mg/1g
PatchTopical5000 mg/1h
LiquidTopical1.27 g/100mL
PatchTopical6500 mg/1h
PatchTopical6500 mg/8h
PatchTopical5000 mg/8h
PatchTransdermal5000 mg/8h
LiquidTopical40 mg/1mL
LiquidTopical0.0127 g/1mL
LiquidTopical4 g/100mL
PatchTransdermal6500 mg/8h
CreamTopical28 g/90mL
GelTopical12 mg/1mL
CreamTopical70 mg/1mL
GelTopical80 mg/1mL
LiquidTopical80 g/1000g
SprayTopical80 g/1000g
StickTopical0.05138 g/1g
SolutionTopical35 mg/1mL
CreamTopical35 mg/1mL
LozengeOral7.6 1/1
LozengeOral8.6 1/1
TapeTopical
Aerosol, sprayPercutaneous; Topical; Transdermal
Aerosol, sprayCutaneous; Topical; Transdermal
LiquidTopical1.05 g/84g
CreamTopical0.2 g/4g
PatchTopical30 mg/1
PatchTopical2.5 mg/100mg
OintmentTopical0.31 g/100g
GelTopical70 mg/1L
SprayTopical70 mg/1L
SprayTopical700 mL/1L
OintmentEnteral
SprayTopical5 mL/100mL
LotionTopical0.15 g/100g
MouthwashOral
RinsePeriodontal
SprayTopical10 g/100mL
GelTopical3.2 g/100mL
GelTopical3 g/100mL
LiquidTopical3 g/100mL
GelTopical3.969 g/113.4g
GelTopical5 g/113.4g
GelTopical3.969 g/90g
CreamTopical3.7 g/100g
LotionTopical1 g/100g
CreamTopical12.5 mg/1g
CreamTopical1.4125 g/113g
LozengeOral2.8 mg/1
PatchTopical5 mg/100mg
GelTopical1.25 g/100g
PowderTopical0.15 g/100g
StickTopical1.34 g/57g
Gel, dentifriceTopical10 mg/1g
CreamTopical10 g/100g
MouthwashBuccal
SolutionTopical100 mg/1mL
PatchTopical; Transdermal
CreamTopical4 g/100g
SprayTopical9 g/100mL
StickTopical2.6 mg/1g
CreamTopical25 mg/1mL
PatchTopical4.62 g/100g
LinimentTopical3.7 g/100mL
GelTopical3 g/120mL
GelTopical2.4 mg/120mL
GelTopical3 mg/120mL
GelTopical1.5 g/60mL
GelTopical50 mg/1g
PatchTopical50 mg/1
GelTopical4.5 g/100g
GelTopical5.085 g/113g
SprayTopical11.8 g/118mL
LozengeOral9.1 mg/1
LozengeOral5.97 mg/1
LiquidTopical4.2 mL/60mL
PatchTopical0.5 mg/1
GelTopical1 g/10mL
GelTopical8.9 g/89mL
LotionTopical5.11 g/113g
GelTopical30 mg/1g
GelTopical2.1 g/60mL
GelTopical4.0 g/100mL
GelTopical0.03 g/1g
PatchTopical56 mg/1g
PatchTopical0.3 g/1
PatchTopical0.3 g/6g
GelTopical35 mg/1mL
GelTopical105 mg/1mL
StickTopical100 mg/1g
StickTopical105 mg/1g
LiquidTopical105 mg/1mL
SprayTopical105 mg/1mL
SprayTopical590 mg/1mL
PatchTopical0.156 g/1
PatchTopical0.348 g/1
SalveTopical1 g/100g
SalveTopical1.1 g/100g
SoapTopical1 g/100mL
GelTopical2.0 g/100g
GelTopical.02 g/1g
PowderTopical1.5 mg/1g
PowderTopical10 mg/1g
LiquidTopical70 mg/1mL
CreamTopical100 mg/1mL
CreamTopical170 g/90mL
GelTopical0.025 g/1g
OintmentRespiratory (inhalation)
OintmentTopical
LiquidTopical5 mg/1mL
CreamTopical0.5 g/100g
CreamTopical40 mg/1g
PatchTopical0.05 mg/1
LotionTopical5 mg/1000mL
OilTopical0.08 kg/1kg
OilTopical8 g/100mL
CreamTopical125 mg/1mL
OintmentTopical1.25 g/100mL
CreamTopical1.25 g/100mL
CreamTopical1.5 g/100g
LiquidTopical0.25 g/100mL
LiquidTransdermal
ShampooTopical0.3 g/100mL
OilTopical1.5 g/50g
LozengeOral4.5 mg/1
SalveTopical27.6 mg/1g
LozengeOral
GelTopical2 g/100g
GelTopical
GelTopical1 mg/100mL
GelTopical0.1 mg/1mL
CreamTopical20 mg/1g
LiquidNasal
CreamTopical0.075 g/1g
SprayTopical16 g/100mL
PatchTopical240 mg/1
PatchTopical500 mg/1
PatchTopical875 mg/1
PatchTopical400 mg/1
LiquidTopical16 g/100mL
PatchTopical5 g/100g
LipstickTopical
Aerosol, sprayTopical6 mL/60mL
GelTopical0.46 L/3.8L
OintmentTopical13 mL/90mL
SwabTopical.96 mL/8mL
GelTopical10 g/100mL
GelTopical4 g/100g
PatchTopical5 g/1
PatchTopical1.14 g/100g
PatchTopical100 mg/5mg
Granule, for solutionOral490 mg/5g
SprayTopical16 g/100g
GelTopical16 g/100g
CreamTopical10 g/100mL
SprayTopical160 mg/1mL
LozengeOral16.0 mg/1
LozengeOral13.2 mg/1
LozengeOral15.3 mg/1
GelTopical1.2 g/100mL
Granule, for solutionTopical11.7 mg/1mL
PatchTopical0.75 g/1
GelTopical2.5 g/100mL
PatchTopical5 mg/1
PatchTopical336 mg/1
PatchTopical5 mg/1g
LozengeOral7.2 mg/7.2mg
TabletOral5.8 mg/5.8mg
TabletOral7.5 mg/7.5mg
TapeCutaneous; Extracorporeal0.05 g/1g
LotionRespiratory (inhalation)
PatchTopical0.05 g/1g
GelTopical36 mg/1mL
LiquidTopical160 mg/1mL
LozengeOral20 mg/1
Gel, dentifriceDental
LozengeOral4 mg/1
LotionTopical1 mg/1mL
CreamTopical0.025 g/1g
SprayTopical60 mg/1mL
SolutionTopical60 mg/1mL
LiquidTopical16 g/100g
Patch, extended releaseTransmucosal2.5 mg/194.851
Patch, extended releaseTransmucosal2.5 mg/194.85mg
Tablet, extended releaseOral; Topical2.5 mg/150mg
KitTopical
LozengeTopical5.8 mg/1
CreamTopical1.8 g/100g
LotionTopical1.5 mg/1g
LiquidTopical50 mg/1mL
LiquidTopical20 mg/1mL
OilTopical3.5 g/100mL
LiquidTopical30 mg/1mL
Aerosol, sprayTopical3 g/100mL
SprayTopical
PatchTopical0.5 g/1g
GelTopical0.06 g/1g
GelTopical3.89 g/100g
GelTopical4.58 g/100g
CreamTopical40 mg/1mL
SprayTopical3.7 mg/1g
SolutionTopical
CreamTopical2.625 g/75g
GelTopical80 mg/1g
CreamTopical100 mg/1g
PatchCutaneous
LozengeOral8.3 mg/1
LozengeOral8.5 mg/1
SalveTopical
CreamTopical50 mg/1mL
LiquidTopical35 mg/1mL
DiscTopical
PatchTopical4 g/1
SprayTopical1000 mg/100mL
SprayTopical1700 mg/100mL
SprayTopical865.4 mg/50mL
CreamTopical60 mg/1mL
LiquidTopical2.5 g/100mL
SprayTopical1.25 g/100mL
PatchTopical0.056 g/1g
CreamTopical2.8 g/56g
StickTopical0.035 g/7g
GelDental
SprayTopical4 g/100mL
CreamTopical12.13 mg/1mL
OintmentTopical9.6 mL/60mL
LotionTopical0.1 g/100mL
GelTopical100 mg/1mL
PlasterTopical; Transdermal
SprayTopical80 mg/1mL
GelTopical2 g/100mL
GelTopical4 g/100mL
StickTopical20 mg/1g
PatchTopical750 mg/1
GelTopical35 mg/1g
SprayTopical100 mg/1g
GelTopical33 mg/1mL
LotionTopical12.5 mg/1mL
SwabTopical
SolutionOral
SprayTopical2.25 g/100mL
GelTopical0.07 g/1g
GelTopical0.16 g/1g
KitOral; Topical
CreamTopical16 g/1
SprayTopical16 g/1
Granule, for solutionOral270 mg/6g
CreamTopical1.25 mg/1mL
CrystalTopical
LotionTopical13.5 mg/1mL
CreamTopical0.1 g/100mL
OilTopical24 mg/1mL
GelTopical4.2 mg/100mL
GelTopical5 mg/1g
SprayOropharyngeal
LozengeOral9 mg/1
LozengeOral8.4 mg/1
SprayOral; Topical
OintmentTopical1 g/100g
LotionTopical0.005 g/1g
PowderTopical0.008 g/1g
PowderTopical0.8 g/100g
SprayTopical1 g/100g
LotionTopical0.0015 g/1g
PowderTopical0.0015 g/1g
CreamTopical16 g/100g
CreamTopical6.25 g/100g
CreamTopical62.5 mg/1mL
LotionCutaneous
OilTopical20 mg/500mg
CreamTopical5 g/100mL
LiquidTopical5 g/100mL
LozengeOral7 mg/1
PlasterTransdermal35 mg/1
LozengeOral5.7 mg/1
LozengeOral6.8 mg/1
LozengeOral1.8 mg/1
LozengeOral8.8 mg/1
LozengeOral8.2 mg/1
LozengeOral6.4 mg/1
LozengeOral4.3 mg/1
LozengeOral2.5 mg/1
LozengeOral2.7 mg/1
LozengeOral4.6 mg/1
LozengeOral3.2 mg/1
LozengeOral9.4 mg/1
LozengeOral3.7 mg/1
LozengeOral6.6 mg/1
LozengeOral6.7 mg/1
LozengeOral2.9 mg/1
LozengeOral15 mg/1
LozengeOral3.1 mg/1
LozengeOral18 mg/1
SyrupOral0.1 g/100mL
GelTopical2.0 g/100mL
PoulticeTransdermal280 mg/12g
GelTopical3.5 mg/100mL
SprayTopical10.4 g/100g
LotionTopical4 g/100g
GelTopical3402 mg/85.05g
LotionTopical9068 mg/226.7g
GelTopical2832 mg/70.8g
SprayTopical8925 mg/85g
CreamTopical7.4 g/100g
CreamTopical
MouthwashDental0.2 g/100mL
MouthwashDental200 mg/100mL
GelTopical5 g/100g
SolutionTopical5 g/100g
CreamTopical2 mg/100mL
GelTopical8 mg/100mL
GelTopical8 g/8g
StickTopical.1 g/1g
LozengeOral4.8 mg/1
SprayTopical0.06 g/1g
LozengeOral5.5 mg/1
LozengeOral1.6 mg/1
LozengeOral6 mg/1
LozengeOral5.5 mg/2.51
CreamTopical70 mg/1g
LozengeOral9.99 mg/1
LozengeOral3 mg/1
LozengeOral3.18 mg/1
LozengeOral7.5 1/1
PastilleOral7.6 mg/1
LozengeOral3.9 mg/1
LozengeOral8.6 mg/2.5g
CreamTopical12.5 mg/1mL
GelTopical2.27 g/227g
PatchTopical285 mg/5700mg
LiquidTopical16 mg/100mL
GelTopical0.3 g/100mL
GelTopical34.79 mg/1mL
CreamTopical2 mg/1g
GelTopical2.84 mg/227mg
GelTopical.02 g/100g
CreamTopical30 mg/1g
GelTopical16.95 g/113g
GelTopical55 mg/1mL
SprayTopical89 mg/1mL
PatchTopical205.50 mg/1
PatchTopical428.50 mg/1
PatchTopical205.5 mg/1
PatchTopical50.25 mg/1
PatchTopical866.25 mg/1
PatchTopical787.5 mg/1
PatchTopical210 mg/1
PatchTopical29.3 mg/1
LiquidTopical140.8 mg/1mL
PatchTopical750.00 mg/1
SprayTopical0.16 g/1mL
OilTopical16 g/100mL
LiquidTopical12.5 mg/1g
GelTopical5 mg/5mL
CreamTopical0.525 g/105g
CreamTopical2.5 g/500g
LiquidTopical0.1 g/100mL
CreamTopical2.2 g/100g
SoapTopical4 mg/1mL
LozengeOral5 mg/100mg
CreamTopical1.8 g/100mL
CreamTopical50 mg/1g
LotionTopical8.5 g/100mL
LiquidTopical1.4 g/28g
LiquidTopical10 g/100mL
ShampooTopical1 mg/1mL
GelTopical6 g/120g
LotionTopical4.49 g/100mL
StickTopical
CreamTopical30 mg/1mL
GelTopical10 g/100g
GelTopical10 mg/1g
LotionTopical8.5 mg/88mL
LozengeOral9.3 mg/1
PowderTopical1 g/100g
RinseOral
CreamDental
CreamTopical3 g/100mL
PlasterTransdermal3.0 g/100g
OilTopical0.8 mg/50mL
GelTopical12.5 mg/1mL
GelTopical20 mg/1g
SprayTopical0.005 g/1g
LozengeOral7.5 mg/1
LozengeOral5.4 mg/1
KitOral
PatchTopical200 mg/1
LozengeOral5 mg/1
Aerosol, sprayTopical
PowderTopical2 g/100g
LozengeOral5.75 mg/1
GelTopical0.24 mg/1mL
LozengeOral1.0 mg/1
LotionTopical11.2 g/224g
LiquidTopical4.2 g/84g
CreamTopical5.6 g/112g
LotionTopical3 g/100g
MouthwashDental; Oral
GelTopical50 mg/1mL
PowderTopical0.1 g/1g
LipstickTopical5 mg/1g
ShampooTopical
LozengeOral8.6 mg/1
GelTopical.07 g/1g
PowderTopical2.26 g/283g
PowderTopical0.42 g/283g
JellyTopical
StickTopical0.9 g/100g
PatchTopical428.5 mg/1
PatchTopical
CreamTopical5 1/85g
LozengeOral5.8 mg/1
ClothTopical0.05 g/1mL
SprayTopical105 mg/1g
CreamTopical5 g/100g
OilTopical6 mg/50mL
PatchTopical15 mg/1g
CreamTopical26 mg/1mL
LozengeOral0.7 g/1g
LozengeOral0.86 g/1g
OilTopical0.5 mg/50mL
PowderTopical2.8 g/283g
PowderTopical2.83 g/283g
SprayTopical2 g/100mL
PatchTopical440 mg/1
PatchTopical600 mg/1
PatchTopical910 mg/1
LozengeOral5.4 1/1
PastilleOral0.005 g/4g
PastilleOral5.8 mg/1
LozengeOral8.0 mg/1
PastilleOral20 mg/1
OintmentTopical27 mg/1g
GelTopical30 mg/1mL
LotionTopical
LotionTopical1.3 g/100g
SalveTopical0.5 g/100g
LinimentPercutaneous; Transdermal1 g/3500mL
SalveTopical1 g/1500g
CreamTopical4 g/100mL
CreamTopical15 mg/1mL
GelTopical0.02 g/1g
Aerosol, foamTopical100 mg/1g
GelTopical160 mg/1g
SolutionTopical40 mg/1mL
GelTopical160 mg/1mL
GelTopical40 mg/1g
CreamTopical0.028 g/28g
CreamTopical0.106 g/106g
CreamTopical0.224 g/224g
LiquidTopical1.8 mL/90mL
CreamTopical3 g/100g
CreamTopical1.5 g/100mL
SprayOral
CreamTopical2.5 g/100g
GelTopical3.5 g/100mL
GelTopical2.5 g/100g
GelTopical25 mg/1g
CreamTopical1.05 g/42g
GelTopical6 g/100mL
SprayTopical15.75 g/100mL
SprayTopical100 mg/1mL
CreamTopical5 uL/1mL
TapeTopical10 g/100g
PillVaginal0.5 g/100g
LotionTopical60 mg/1mL
OintmentRectal275 mg/48.2g
MouthwashOral0.3 mg/1mL
LozengeOral2.1 mg/1
LozengeOral3 1/1
PastilleOral0.18 mg/1
PastilleOral4.8 mg/1
LozengeOral1.5 mg/1
LozengeOral2.0 mg/1
LozengeOral3.5 mg/1
LozengeOral1.2 mg/1
GelTopical3 g/100g
LozengeOral2 mg/3g
CreamTopical10 mg/1g
LotionTopical5 mg/1g
SprayTopical0.16 g/1g
SprayTopical5 g/100mL
LozengeOral8 mg/1
Aerosol, sprayTopical1 mg/100mg
Aerosol, sprayTopical5 mg/100mg
CreamTopical10 mg/100mg
LiquidTopical10 mg/100mg
SprayTopical0.1 mg/100mg
Aerosol, foamTopical5 mg/100mg
LinimentTopical
LiquidTopical0.2 g/10mL
Tablet, solubleOral
PowderOral
SprayTopical0.5 g/100mL
OintmentTopical1.25 g/100g
OilTransdermal100 mg/50mL
GelTopical0.33 mg/660mL
GelTopical0.63 g/632.19g
LozengeOral10 mg/1
PastilleOral10 mg/1
GelTopical85 mg/1mL
StripDental
Film, solubleOral
PasteTopical
LozengeOral1.9 mg/1
CreamTopical1.3 g/100g
CreamTopical8 g/100g
GelTopical7 g/100mL
LiquidTopical6 g/100mL
CreamTopical14 g/280g
GranuleTopical1.6 mg/1g
LiquidTopical2.23 mg/1mL
OilTopical12.18 mg/1mL
OilTopical17.62 mg/1mL
SprayTopical10 g/100g
CreamTopical2 g/100mL
OintmentTopical2.5 g/100mL
OintmentTopical3.5 g/100mL
PatchTopical105 mg/1
CreamTopical6 g/100mL
Aerosol, sprayTopical6 g/100mL
GelTopical15 mg/1mL
GelTopical17.5 mg/1mL
LiquidTopical0.16 g/1mL
GelTopical11 g/100mL
LiquidTopical10 g/100g
SprayTopical10.5 g/100g
PatchTopical160 mg/1mL
StickTopical10 g/100g
TinctureTopical
GelTopical2.4 g/120g
SprayTopical7 g/100mL
GelTopical4.54 g/1g
GelTopical10 g/100L
PatchTopical0.2 1/1
PatchTopical.05 mg/1g
PatchTopical50 mg/1g
PatchTopical6 g/1
PatchTopical30 mg/1mL
PatchTopical70 mg/1g
GelTopical4.6 g/100g
CreamTopical35 mg/1g
CreamTopical4.25 g/85g
LotionTopical160 mg/1mL
PatchTopical775 mg/1
PatchTopical5 g/1001
PatchTopical1.22 g/1
PatchTopical350 mg/1
LotionTopical7.5 g/100g
LiquidOral
GelTopical1.0 g/100g
GelTopical31 mg/1mL
SprayTopical104 mg/1mL
PowderTopical
PowderTopical20 mg/2g
GelTopical1 g/100g
Lotion / shampooTopical
CreamTopical20 mg/1mL
ShampooTopical0.1 g/100mL
OintmentTopical13 g/100g
OilTopical15 g/100mL
GelTopical120 mg/1g
GelTopical120 mg/1mL
LiquidTopical140 mg/1mL
GelTopical40 mg/1mL
GelTopical2 mL/100mL
CreamTopical80 mg/1mL
GelTopical4.54 g/227g
SprayTopical10.5 g/10.5mL
CreamCutaneous; Topical
OintmentCutaneous; Topical
GelCutaneous; Topical
CreamTopical4 g/60mL
SprayTopical8 g/100mL
GelTopical8 g/100mL
GelTopical10.5 g/10.5mL
OintmentTopical16 g/16mg
LozengeOral2 mg/1
LotionTopical3 g/100mL
PatchPercutaneous; Topical; Transdermal
LiquidTopical80 mg/1mL
PatchTopical0.875 g/100g
CreamTopical1.25 g/100g
GelTopical3.5 mg/1L
LiquidTopical34.86 g/1L
LiquidTopical34.79 g/1L
CreamTopical118.29 mL/100mL
LotionTopical1.5 g/100mL
LotionTopical0.5 g/100mL
LotionTopical1.25 g/100mL
OintmentTopical12.7 mg/1g
LozengeOral6.1 mg/1001
LiquidTopical12.5 mg/1mL
CreamTopical3.0 g/100g
LiquidTopical1.2 mg/15mL
OintmentTopical0.2 g/100g
OintmentTopical937.5 mg/1g
GelTopical27.5 mg/1g
OilTopical7 mg/50mL
PatchTopical50 g/1
GelTopical40 mg/1
CreamTopical0.006 g/0.1g
CreamTopical6 mg/100mL
GelTopical6.0 g/100g
GelTopical33.2 g/355mL
GelTopical8.3 g/88.5mL
KitTopical24.03 mg/1mL
SprayTopical4 g/4mL
PatchTopical1000 mg/1
PatchTopical900 mg/1
GelPercutaneous; Topical; Transdermal
Aerosol, foamPercutaneous; Topical; Transdermal
OintmentPercutaneous; Topical; Transdermal
PoulticePercutaneous; Topical; Transdermal175 mg/1
GelTopical150 mg/1g
LiquidTopical
GelTopical140 mg/1mL
Paste, dentifriceTopical0.2 g/100g
PastilleOral0.69 mg/1
PlasterTopical
GelTopical12.5 mg/1g
GelTopical12.6 mg/1g
GelTopical2.6 mg/100g
LiquidTopical1 g/100mL
KitTopical10 mg/1g
StickTopical10 mg/1g
PatchTopical0.85 g/1
PatchTopical0.85 g/17g
CreamOral6 g/100mL
SprayTopical5 mg/1mL
MouthwashDental10 mg/20mL
LozengeOral6.5 mg/1
CreamTopical15 mg/1g
GelTopical2.25 g/100g
MouthwashDental
Solution / dropsTopical
GelTopical2 mg/100mL
CreamTopical17.5 mg/1mL
TabletOral5.8 mg/1
LiquidTopical100 mg/1mL
GelTopical6 g/100g
GelTopical0.08 g/1g
OilTopical1 g/93mL
LozengeOral5.8 1/1
LozengeOral6.9 mg/1
LozengeOral2.6 mg/1
LozengeOral4.1 mg/1
LozengeOral7.6 mg/1
LozengeOral5.52 mg/1
LozengeOral1.1 mg/1
LozengeOral2.2 mg/1
OintmentTopical1 mg/1g
CreamTopical14 mg/1mL
LinimentTransdermal3.5 mg/100mL
OilTopical24.56 mg/1mL
OilTopical1.3 mg/50mg
OintmentTopical8 g/100g
PatchTopical4 g/100g
StickTopical0.6 g/100g
CreamTopical2 g/100g
LozengeOral5.3 mg/1
CreamTopical130 mg/1g
GelTopical60 mg/1mL
GelTopical.04 g/1g
GelTopical3.9 g/100mL
SprayTopical6 g/100mL
PastilleOral2.5 mg/1
LozengeOral6 mg/4.2g
PatchTransdermal3 g/1
PatchTransdermal
PlasterTransdermal
CreamTopical0.1 g/100g
LiquidTopical0.002 g/4mL
LiquidTopical0.06 g/120mL
OintmentTopical24 mg/1g
PoulticeTransdermal
DressingOral
CreamTopical1.4 g/100g
LotionTopical0.5 g/100g
PatchTopical150 mg/1
PatchTopical300 mg/1
PatchTopical375 mg/1
GelTopical5.0 g/100mL
SprayTopical10.5 g/100mL
LiquidTopical5 g/100g
GelTopical8.5 g/100mL
LotionTopical1.35 mg/100mL
GelTopical4.56 g/114g
LotionTopical8 g/100g
GelTopical5 g/100mL
GelTopical1.25 g/100mL
CreamTopical45 mg/1mL
LiquidTopical25 g/100g
LozengeOral1.7 mg/1
LozengeOral3.3 mg/1
GelTopical2.69 g/60mL
LotionTopical2 g/50mL
LiquidTopical0.9 g/100mL
GelTopical0.1 g/100g
SprayOral2 g/100mL
PatchTopical5 1/1
OilTransdermal
OilTopical
LotionTopical1 g/100mL
CreamTopical0.03 g/1g
LozengeOral5.8 mg/1mg
GelTopical3 g/227g
LinimentPercutaneous; Transdermal3 g/100mL
LinimentPercutaneous; Transdermal
PatchTopical10 mg/1000mg
GelTopical20 g/1L
GelTopical37 mg/1g
GelTopical37 mg/1mL
SprayTopical37 mg/1g
GelTopical70 mg/1g
SprayTopical160 mg/1g
SprayTopical90 mg/1mL
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US8809615No2014-08-192030-01-03US flag
US9233184No2016-01-122027-08-01US flag

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.558 mg/mLALOGPS
logP2.68ALOGPS
logP2.66ChemAxon
logS-2.4ALOGPS
pKa (Strongest Acidic)19.55ChemAxon
pKa (Strongest Basic)-0.81ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area20.23 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity47.45 m3·mol-1ChemAxon
Polarizability19.68 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Targets

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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Agonist
General Function
Calcium channel activity
Specific Function
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalypto...
Gene Name
TRPM8
Uniprot ID
Q7Z2W7
Uniprot Name
Transient receptor potential cation channel subfamily M member 8
Molecular Weight
127684.035 Da
References
  1. Liu J, Liu L, Zhao M, Ding N, Ge N, Daugherty SL, Beckel JM, Wang S, Zhang X: Activation of TRPM8 channel inhibits contraction of the isolated human ureter. Neurourol Urodyn. 2021 Aug;40(6):1450-1459. doi: 10.1002/nau.24689. Epub 2021 May 20. [Article]

Drug created at June 24, 2018 13:18 / Updated at November 27, 2021 01:19