Transient receptor potential cation channel subfamily M member 8

BE0001186ProteinHumansTRPM8

Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). It is acted on by 16 drugs in DrugBank.

Gene name
TRPM8
UniProtKB entry
Q7Z2W7Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,104 residues · 127,684 Da
Also known as
Long transient receptor potential channel 6 · LTrpC-6 · LTRPC6 · Transient receptor potential p8 · Trp-p8

Resolves to

Protein
UniProtQ7Z2W7UniProt nameTRPM8_HUMAN
Gene
HGNCHGNC:17961NCBI Gene79054GenBank20147036GeneCardsTRPM8
Pharmacology
IUPHAR/GtoPdb500KEGGhsa:79054
Structure
PDB8BDCPDB9P8YPDB9PB5
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transient receptor potential cation channel subfamily M member 8, how selective are they, and which programs against it are still in active trials?

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