Transient receptor potential cation channel subfamily A member 1

BE0001122ProteinHumansTRPA1

Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:33152265). It is acted on by 35 drugs in DrugBank.

Gene name
TRPA1
UniProtKB entry
O75762Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,119 residues · 127,500 Da
Also known as
ANKTM1 · Ankyrin-like with transmembrane domains protein 1 · p120 · Transformation-sensitive protein p120 · Wasabi receptor

Resolves to

Protein
UniProtO75762UniProt nameTRPA1_HUMAN
Gene
HGNCHGNC:497NCBI Gene8989GenBank3287188GeneCardsTRPA1
Pharmacology
IUPHAR/GtoPdb485KEGGhsa:8989
Structure
PDB3J9PPDB6HC8PDB6PQO
Drugs

What you can answer from here — as of September 07, 2019

35DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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68+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transient receptor potential cation channel subfamily A member 1, how selective are they, and which programs against it are still in active trials?

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