Centella asiatica

Identification

Generic Name

Centella asiatica

DrugBank Accession Number

DB14256

Background

Centella asiatica is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Type

Biotech

Groups

Approved, Experimental, Investigational

Synonyms

• Asiatic Pennywort Whole
• Bacopa Monniera Whole Extract
• Bacopa Whole
• Brahmi Whole
• Centella Asiatica Extract
• Coastal Water-hyssop Whole
• Gotu Kola
• Gotu Kola Whole
• Herba Centellae
• Hydrocotyle
• Hydrocotyle Asiatica
• Indian Pennywort Whole
• Ji Xue Cao Whole
• Jixuecao Whole
• Luo De Da Whole
• Ma Ti Cao Whole
• Mandukaparni Whole
• Sheep-rot Whole
• Spadeleaf Whole
• Thankuni Whole
• Water Hyssop Whole

Pharmacology

Indication

Not Available

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Associated Conditions

• Burns first degree
• Capillary fragility
• Pruritus
• Radiation Burn
• Second Degree Burns
• Skin Ulcer
• Venous Insufficiency
• Damaged skin

Associated Therapies

• Massage
• Skin Care

Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drug	Interaction
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Acetazolamide	The therapeutic efficacy of Acetazolamide can be decreased when used in combination with Centella asiatica.
Amifampridine	The risk or severity of seizure can be increased when Centella asiatica is combined with Amifampridine.
Amobarbital	The therapeutic efficacy of Amobarbital can be decreased when used in combination with Centella asiatica.
Brexanolone	The therapeutic efficacy of Brexanolone can be decreased when used in combination with Centella asiatica.
Brivaracetam	The therapeutic efficacy of Brivaracetam can be decreased when used in combination with Centella asiatica.
Bupropion	The risk or severity of seizure can be increased when Bupropion is combined with Centella asiatica.
Butalbital	The therapeutic efficacy of Butalbital can be decreased when used in combination with Centella asiatica.
Cannabidiol	The therapeutic efficacy of Cannabidiol can be decreased when used in combination with Centella asiatica.
Carbamazepine	The therapeutic efficacy of Carbamazepine can be decreased when used in combination with Centella asiatica.
Cenobamate	The therapeutic efficacy of Cenobamate can be decreased when used in combination with Centella asiatica.

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Food Interactions

• Take with food.

Products

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Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Centellaca A Clear Relaxing Toner	Liquid	55.45 mg/100mL	Topical	Wow Ventures	2015-05-01	2017-07-15
Cothilyne- Asp-tct 89.5	Spray; Tincture	89.5 %	Topical	Haemacure Corporation	1995-12-31	1999-10-05
Elcure Curekin	Shampoo	3000 mg/300mL	Topical	Elcure Co., Ltd.	2013-07-18	2017-04-20
eves centella 20 V1 Volume Ampoule	Liquid	1 g/100mL	Topical	eveskorea	2022-11-22	Not applicable
eves volume V2 essence	Liquid	1 g/100mL	Topical	eveskorea	2022-11-22	Not applicable
LANBELLE Cleansing	Gel	0.01 g/100mL	Topical	Tamlatamanu Inc.	2018-03-27	Not applicable
Shynomore Lubricant	Gel	15 g/100mL	Vaginal	Bluette Co., Ltd.	2018-01-01	Not applicable
StemCell TeN 10 Revolutionary skin theraphy	Cream	0.3 mg/31	Topical	Dr.Gene Co.,Ltd	2015-04-01	Not applicable
Troiareuke Acsen Toc Toner	Liquid	0.30 g/100mL	Topical	Mk Universal Inc.	2018-05-01	2018-12-01
W.skin Natural Fermented Grain Mask Sheet	Liquid	0.01 g/100g	Topical	J&J COMPANY	2021-05-08	Not applicable

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
ACTS38 BoswelliaGel	Centella asiatica (0.01 g/100mL) + Sodium hyaluronate (0.01 g/100mL) + Indian frankincense (1.2 g/100mL) + N-Acetylglucosamine (0.1 g/100mL)	Gel	Topical	A-Lot Biologics Inc	2022-09-07	Not applicable
ACTS38 BoswelliaGel (100ml)	Centella asiatica (0.01 g/100mL) + Sodium hyaluronate (0.01 g/100mL) + Indian frankincense (1.2 g/100mL) + N-Acetylglucosamine (0.1 g/100mL)	Gel	Topical	A-Lot Biologics Inc	2022-10-23	Not applicable
Ato Standard Intensivecream	Centella asiatica (0.003 g/100g) + Ceramide NP (0.0006 g/100g) + Macadamia oil (2 g/100g) + Panthenol (0.75 g/100g)	Cream	Topical	TIMEBIO Co., Ltd	2020-12-03	Not applicable
Ato Standard Premium Mildcream	Centella asiatica (0.005 g/100g) + Ceramide NP (0.0018 g/100g) + Shea butter (3 g/100g)	Cream	Topical	TIMEBIO Co., Ltd	2021-02-01	Not applicable
Centella 65 Green Tea Pack	Centella asiatica (65 g/100g) + Green tea leaf (1 g/100g)	Cream	Topical	Ami Cosmetic Co.,Ltd.	2016-02-23	2019-03-28
Dr.Different CICA Metal Calming Pad	Centella asiatica (0.045 g/90mL) + Madecassoside (0.009 g/90mL)	Liquid	Topical	Dareun Cosmetics Co., Ltd.	2021-09-01	Not applicable
DRH Ultimate Calming Mask Serum	Centella asiatica (0.28 g/28g) + Chamaemelum nobile flower (0.02 g/28g) + Purslane (0.28 g/28g)	Patch	Topical	New & New Co.,ltd.	2016-10-01	2018-12-01
INCORD Disposable Feminine Cleansing	Centella asiatica (0.09 g/100g) + Propolis wax (0.001 g/100g) + Tea tree oil (0.001 g/100g)	Gel	Vaginal	Hucordbio Co., Ltd.	2022-04-01	Not applicable
Laser Rejuvenation restoring damage skin	Centella asiatica (0.001 mL/1mL) + Acetyl hexapeptide-3 (0.0001 mL/1mL) + Adenosine (0.00004 mL/1mL)	Cream	Topical	Universal Cosmetic Co., Ltd	2010-08-19	Not applicable
Madecassol	Centella asiatica (10 mg/1g) + Neomycin sulfate (3.5 mg/1g)	Ointment	Topical	I World Pharmaceutical Co., Ltd.	2019-10-08	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
ACTS38 BoswelliaGel	Centella asiatica (0.01 g/100mL) + Sodium hyaluronate (0.01 g/100mL) + Indian frankincense (1.2 g/100mL) + N-Acetylglucosamine (0.1 g/100mL)	Gel	Topical	A-Lot Biologics Inc	2022-09-07	Not applicable
ACTS38 BoswelliaGel (100ml)	Centella asiatica (0.01 g/100mL) + Sodium hyaluronate (0.01 g/100mL) + Indian frankincense (1.2 g/100mL) + N-Acetylglucosamine (0.1 g/100mL)	Gel	Topical	A-Lot Biologics Inc	2022-10-23	Not applicable
Ato Standard Intensivecream	Centella asiatica (0.003 g/100g) + Ceramide NP (0.0006 g/100g) + Macadamia oil (2 g/100g) + Panthenol (0.75 g/100g)	Cream	Topical	TIMEBIO Co., Ltd	2020-12-03	Not applicable
Ato Standard Premium Mildcream	Centella asiatica (0.005 g/100g) + Ceramide NP (0.0018 g/100g) + Shea butter (3 g/100g)	Cream	Topical	TIMEBIO Co., Ltd	2021-02-01	Not applicable
Centella 65 Green Tea Pack	Centella asiatica (65 g/100g) + Green tea leaf (1 g/100g)	Cream	Topical	Ami Cosmetic Co.,Ltd.	2016-02-23	2019-03-28
Centellaca A Clear Relaxing Toner	Centella asiatica (55.45 mg/100mL)	Liquid	Topical	Wow Ventures	2015-05-01	2017-07-15
Dr.Different CICA Metal Calming Pad	Centella asiatica (0.045 g/90mL) + Madecassoside (0.009 g/90mL)	Liquid	Topical	Dareun Cosmetics Co., Ltd.	2021-09-01	Not applicable
DRH Ultimate Calming Mask Serum	Centella asiatica (0.28 g/28g) + Chamaemelum nobile flower (0.02 g/28g) + Purslane (0.28 g/28g)	Patch	Topical	New & New Co.,ltd.	2016-10-01	2018-12-01
Elcure Curekin	Centella asiatica (3000 mg/300mL)	Shampoo	Topical	Elcure Co., Ltd.	2013-07-18	2017-04-20
eves centella 20 V1 Volume Ampoule	Centella asiatica (1 g/100mL)	Liquid	Topical	eveskorea	2022-11-22	Not applicable

Categories

Drug Categories

• Agents that reduce seizure threshold
• Angiosperms
• Apiaceae
• Biological Products
• Complex Mixtures
• Embryophyta
• Eukaryota
• Pharmaceutical Preparations
• Plant Extracts
• Plant Preparations
• Streptophyta
• Terpenes
• Tracheophyta
• Viridiplantae

Classification

Not classified

Affected organisms

Not Available

Chemical Identifiers

UNII

4YS74Q4G4J

CAS number

Not Available

References

General References

Not Available

External Links

RxNav

1807125

Wikipedia

Centella_asiatica

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Unknown Status	Treatment	Dry Skin / Type 2 Diabetes Mellitus	1
2	Completed	Treatment	Diabetic Neuropathies	1
1	Completed	Treatment	Gingival Diseases	1
1	Recruiting	Treatment	Alzheimer's Disease (AD) / Mild Cognitive Impairment (MCI)	1
0	Active Not Recruiting	Screening	Elderly / Healthy Subjects (HS)	1
0	Completed	Treatment	To Prevent Scar Formation for Patients Underwent Surgery	1
0	Enrolling by Invitation	Treatment	Promotion of wound healing	1
0	Terminated	Screening	Cognitive Impairment (CI) / Elderly	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Gel	Topical
Insert	Vaginal
Liquid	Topical	55.45 mg/100mL
Tablet	Oral
Spray; tincture	Topical	89.5 %
Patch	Topical
Shampoo	Topical	3000 mg/300mL
Liquid	Topical	1 g/100mL
Gel	Vaginal
Gel	Topical	0.01 g/100mL
Cream	Topical
Ointment	Topical
Ointment		1 %
Gel	Vaginal	15 g/100mL
Cream	Topical	0.3 mg/31
Liquid	Topical	0.30 g/100mL
Liquid	Topical
Liquid	Topical	0.01 g/100g
Cream	Topical	0.001 g/100g
Gel	Topical	0.1 g/100mL

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

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Drug created at July 05, 2018 17:13 / Updated at June 22, 2021 18:16