Centella asiatica

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Centella asiatica
DrugBank Accession Number
DB14256
Background

Centella asiatica is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Type
Biotech
Groups
Approved, Experimental, Investigational
Synonyms
  • Asiatic Pennywort Whole
  • Bacopa Monniera Whole Extract
  • Bacopa Whole
  • Brahmi Whole
  • Centella Asiatica Extract
  • Coastal Water-hyssop Whole
  • Gotu Kola
  • Gotu Kola Whole
  • Herba Centellae
  • Hydrocotyle
  • Hydrocotyle Asiatica
  • Indian Pennywort Whole
  • Ji Xue Cao Whole
  • Jixuecao Whole
  • Luo De Da Whole
  • Ma Ti Cao Whole
  • Mandukaparni Whole
  • Sheep-rot Whole
  • Spadeleaf Whole
  • Thankuni Whole
  • Water Hyssop Whole

Pharmacology

Indication

Not Available

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Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe therapeutic efficacy of Acetazolamide can be decreased when used in combination with Centella asiatica.
AmifampridineThe risk or severity of seizure can be increased when Centella asiatica is combined with Amifampridine.
AmobarbitalThe therapeutic efficacy of Amobarbital can be decreased when used in combination with Centella asiatica.
BrexanoloneThe therapeutic efficacy of Brexanolone can be decreased when used in combination with Centella asiatica.
BrivaracetamThe therapeutic efficacy of Brivaracetam can be decreased when used in combination with Centella asiatica.
BupropionThe risk or severity of seizure can be increased when Bupropion is combined with Centella asiatica.
ButalbitalThe therapeutic efficacy of Butalbital can be decreased when used in combination with Centella asiatica.
CannabidiolThe therapeutic efficacy of Cannabidiol can be decreased when used in combination with Centella asiatica.
CarbamazepineThe therapeutic efficacy of Carbamazepine can be decreased when used in combination with Centella asiatica.
CenobamateThe therapeutic efficacy of Cenobamate can be decreased when used in combination with Centella asiatica.
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Food Interactions
  • Take with food.

Products

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dosage, form, labeller, route of administration, and marketing period.
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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Centellaca A Clear Relaxing TonerLiquid55.45 mg/100mLTopicalWow Ventures2015-05-012017-07-15US flag
Cothilyne- Asp-tct 89.5Spray; Tincture89.5 %TopicalHaemacure Corporation1995-12-311999-10-05Canada flag
Elcure CurekinShampoo3000 mg/300mLTopicalElcure Co., Ltd.2013-07-182017-04-20US flag
eves centella 20 V1 Volume AmpouleLiquid1 g/100mLTopicaleveskorea2022-11-22Not applicableUS flag
eves volume V2 essenceLiquid1 g/100mLTopicaleveskorea2022-11-22Not applicableUS flag
LANBELLE CleansingGel0.01 g/100mLTopicalTamlatamanu Inc.2018-03-27Not applicableUS flag
Shynomore LubricantGel15 g/100mLVaginalBluette Co., Ltd.2018-01-01Not applicableUS flag
StemCell TeN 10 Revolutionary skin theraphyCream0.3 mg/31TopicalDr.Gene Co.,Ltd2015-04-01Not applicableUS flag
Troiareuke Acsen Toc TonerLiquid0.30 g/100mLTopicalMk Universal Inc.2018-05-012018-12-01US flag
W.skin Natural Fermented Grain Mask SheetLiquid0.01 g/100gTopicalJ&J COMPANY2021-05-08Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ACTS38 BoswelliaGelCentella asiatica (0.01 g/100mL) + Sodium hyaluronate (0.01 g/100mL) + Indian frankincense (1.2 g/100mL) + N-Acetylglucosamine (0.1 g/100mL)GelTopicalA-Lot Biologics Inc2022-09-07Not applicableUS flag
ACTS38 BoswelliaGel (100ml)Centella asiatica (0.01 g/100mL) + Sodium hyaluronate (0.01 g/100mL) + Indian frankincense (1.2 g/100mL) + N-Acetylglucosamine (0.1 g/100mL)GelTopicalA-Lot Biologics Inc2022-10-23Not applicableUS flag
Ato Standard IntensivecreamCentella asiatica (0.003 g/100g) + Ceramide NP (0.0006 g/100g) + Macadamia oil (2 g/100g) + Panthenol (0.75 g/100g)CreamTopicalTIMEBIO Co., Ltd2020-12-03Not applicableUS flag
Ato Standard Premium MildcreamCentella asiatica (0.005 g/100g) + Ceramide NP (0.0018 g/100g) + Shea butter (3 g/100g)CreamTopicalTIMEBIO Co., Ltd2021-02-01Not applicableUS flag
Centella 65 Green Tea PackCentella asiatica (65 g/100g) + Green tea leaf (1 g/100g)CreamTopicalAmi Cosmetic Co.,Ltd.2016-02-232019-03-28US flag
Dr.Different CICA Metal Calming PadCentella asiatica (0.045 g/90mL) + Madecassoside (0.009 g/90mL)LiquidTopicalDareun Cosmetics Co., Ltd.2021-09-01Not applicableUS flag
DRH Ultimate Calming Mask SerumCentella asiatica (0.28 g/28g) + Chamaemelum nobile flower (0.02 g/28g) + Purslane (0.28 g/28g)PatchTopicalNew & New Co.,ltd.2016-10-012018-12-01US flag
INCORD Disposable Feminine CleansingCentella asiatica (0.09 g/100g) + Propolis wax (0.001 g/100g) + Tea tree oil (0.001 g/100g)GelVaginalHucordbio Co., Ltd.2022-04-01Not applicableUS flag
Laser Rejuvenation restoring damage skinCentella asiatica (0.001 mL/1mL) + Acetyl hexapeptide-3 (0.0001 mL/1mL) + Adenosine (0.00004 mL/1mL)CreamTopicalUniversal Cosmetic Co., Ltd2010-08-19Not applicableUS flag
MadecassolCentella asiatica (10 mg/1g) + Neomycin sulfate (3.5 mg/1g)OintmentTopicalI World Pharmaceutical Co., Ltd.2019-10-08Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ACTS38 BoswelliaGelCentella asiatica (0.01 g/100mL) + Sodium hyaluronate (0.01 g/100mL) + Indian frankincense (1.2 g/100mL) + N-Acetylglucosamine (0.1 g/100mL)GelTopicalA-Lot Biologics Inc2022-09-07Not applicableUS flag
ACTS38 BoswelliaGel (100ml)Centella asiatica (0.01 g/100mL) + Sodium hyaluronate (0.01 g/100mL) + Indian frankincense (1.2 g/100mL) + N-Acetylglucosamine (0.1 g/100mL)GelTopicalA-Lot Biologics Inc2022-10-23Not applicableUS flag
Ato Standard IntensivecreamCentella asiatica (0.003 g/100g) + Ceramide NP (0.0006 g/100g) + Macadamia oil (2 g/100g) + Panthenol (0.75 g/100g)CreamTopicalTIMEBIO Co., Ltd2020-12-03Not applicableUS flag
Ato Standard Premium MildcreamCentella asiatica (0.005 g/100g) + Ceramide NP (0.0018 g/100g) + Shea butter (3 g/100g)CreamTopicalTIMEBIO Co., Ltd2021-02-01Not applicableUS flag
Centella 65 Green Tea PackCentella asiatica (65 g/100g) + Green tea leaf (1 g/100g)CreamTopicalAmi Cosmetic Co.,Ltd.2016-02-232019-03-28US flag
Centellaca A Clear Relaxing TonerCentella asiatica (55.45 mg/100mL)LiquidTopicalWow Ventures2015-05-012017-07-15US flag
Dr.Different CICA Metal Calming PadCentella asiatica (0.045 g/90mL) + Madecassoside (0.009 g/90mL)LiquidTopicalDareun Cosmetics Co., Ltd.2021-09-01Not applicableUS flag
DRH Ultimate Calming Mask SerumCentella asiatica (0.28 g/28g) + Chamaemelum nobile flower (0.02 g/28g) + Purslane (0.28 g/28g)PatchTopicalNew & New Co.,ltd.2016-10-012018-12-01US flag
Elcure CurekinCentella asiatica (3000 mg/300mL)ShampooTopicalElcure Co., Ltd.2013-07-182017-04-20US flag
eves centella 20 V1 Volume AmpouleCentella asiatica (1 g/100mL)LiquidTopicaleveskorea2022-11-22Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
4YS74Q4G4J
CAS number
Not Available

References

General References
Not Available
RxNav
1807125
Wikipedia
Centella_asiatica

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Unknown StatusTreatmentDry Skin / Type 2 Diabetes Mellitus1
2CompletedTreatmentDiabetic Neuropathies1
1CompletedTreatmentGingival Diseases1
1RecruitingTreatmentAlzheimer's Disease (AD) / Mild Cognitive Impairment (MCI)1
0Active Not RecruitingScreeningElderly / Healthy Subjects (HS)1
0CompletedTreatmentTo Prevent Scar Formation for Patients Underwent Surgery1
0Enrolling by InvitationTreatmentPromotion of wound healing1
0TerminatedScreeningCognitive Impairment (CI) / Elderly1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
GelTopical
InsertVaginal
LiquidTopical55.45 mg/100mL
TabletOral
Spray; tinctureTopical89.5 %
PatchTopical
ShampooTopical3000 mg/300mL
LiquidTopical1 g/100mL
GelVaginal
GelTopical0.01 g/100mL
CreamTopical
OintmentTopical
Ointment1 %
GelVaginal15 g/100mL
CreamTopical0.3 mg/31
LiquidTopical0.30 g/100mL
LiquidTopical
LiquidTopical0.01 g/100g
CreamTopical0.001 g/100g
GelTopical0.1 g/100mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at July 05, 2018 17:13 / Updated at June 22, 2021 18:16