This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Centella asiatica
- DrugBank Accession Number
- DB14256
- Background
Centella asiatica is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
- Type
- Biotech
- Groups
- Approved, Experimental, Investigational
- Synonyms
- Asiatic Pennywort Whole
- Bacopa Monniera Whole Extract
- Bacopa Whole
- Brahmi Whole
- Centella Asiatica Extract
- Coastal Water-hyssop Whole
- Gotu Kola
- Gotu Kola Whole
- Herba Centellae
- Hydrocotyle
- Hydrocotyle Asiatica
- Indian Pennywort Whole
- Ji Xue Cao Whole
- Jixuecao Whole
- Luo De Da Whole
- Ma Ti Cao Whole
- Mandukaparni Whole
- Sheep-rot Whole
- Spadeleaf Whole
- Thankuni Whole
- Water Hyssop Whole
Pharmacology
- Indication
Not Available
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- Associated Therapies
- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcetazolamide The therapeutic efficacy of Acetazolamide can be decreased when used in combination with Centella asiatica. Amifampridine The risk or severity of seizure can be increased when Centella asiatica is combined with Amifampridine. Amobarbital The therapeutic efficacy of Amobarbital can be decreased when used in combination with Centella asiatica. Brexanolone The therapeutic efficacy of Brexanolone can be decreased when used in combination with Centella asiatica. Brivaracetam The therapeutic efficacy of Brivaracetam can be decreased when used in combination with Centella asiatica. Bupropion The risk or severity of seizure can be increased when Bupropion is combined with Centella asiatica. Butalbital The therapeutic efficacy of Butalbital can be decreased when used in combination with Centella asiatica. Cannabidiol The therapeutic efficacy of Cannabidiol can be decreased when used in combination with Centella asiatica. Carbamazepine The therapeutic efficacy of Carbamazepine can be decreased when used in combination with Centella asiatica. Cenobamate The therapeutic efficacy of Cenobamate can be decreased when used in combination with Centella asiatica. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Take with food.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Centellaca A Clear Relaxing Toner Liquid 55.45 mg/100mL Topical Wow Ventures 2015-05-01 2017-07-15 US 
Cothilyne- Asp-tct 89.5 Spray; Tincture 89.5 % Topical Haemacure Corporation 1995-12-31 1999-10-05 Canada 
Elcure Curekin Shampoo 3000 mg/300mL Topical Elcure Co., Ltd. 2013-07-18 2017-04-20 US LANBELLE Cleansing Gel 0.01 g/100mL Topical Tamlatamanu Inc. 2018-03-27 Not applicable US Shynomore Lubricant Gel 15 g/100mL Vaginal Bluette Co., Ltd. 2018-01-01 Not applicable US StemCell TeN 10 Revolutionary skin theraphy Cream 0.3 mg/31 Topical Dr.Gene Co.,Ltd 2015-04-01 Not applicable US Troiareuke Acsen Toc Toner Liquid 0.30 g/100mL Topical Mk Universal Inc. 2018-05-01 2018-12-01 US W.skin Natural Fermented Grain Mask Sheet Liquid 0.01 g/100g Topical J&J COMPANY 2021-05-08 Not applicable US W.skin Stop-aging Son Joo Rum Handcream Plus Cream 0.001 g/100g Topical J&J COMPANY 2021-05-08 Not applicable US Xoul Pure Recovery peeling Gel 0.1 g/100mL Topical Picostech Co.,Ltd. 2018-03-26 2018-06-26 US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Ato Standard Intensivecream Centella asiatica (0.003 g/100g) + Ceramide NP (0.0006 g/100g) + Macadamia oil (2 g/100g) + Panthenol (0.75 g/100g) Cream Topical TIMEBIO Co., Ltd 2020-12-03 Not applicable US Ato Standard Premium Mildcream Centella asiatica (0.005 g/100g) + Ceramide NP (0.0018 g/100g) + Shea butter (3 g/100g) Cream Topical TIMEBIO Co., Ltd 2021-02-01 Not applicable US Centella 65 Green Tea Pack Centella asiatica (65 g/100g) + Green tea leaf (1 g/100g) Cream Topical Ami Cosmetic Co.,Ltd. 2016-02-23 2019-03-28 US Dr.Different CICA Metal Calming Pad Centella asiatica (0.045 g/90mL) + Madecassoside (0.009 g/90mL) Liquid Topical Dareun Cosmetics Co., Ltd. 2021-09-01 Not applicable US DRH Ultimate Calming Mask Serum Centella asiatica (0.28 g/28g) + Chamaemelum nobile flower (0.02 g/28g) + Purslane (0.28 g/28g) Patch Topical New & New Co.,ltd. 2016-10-01 2018-12-01 US INCORD Disposable Feminine Cleansing Centella asiatica (0.09 g/100g) + Propolis wax (0.001 g/100g) + Tea tree oil (0.001 g/100g) Gel Vaginal Hucordbio Co., Ltd. 2022-04-01 Not applicable US Laser Rejuvenation restoring damage skin Centella asiatica (0.001 mL/1mL) + Acetyl hexapeptide-3 (0.0001 mL/1mL) + Adenosine (0.00004 mL/1mL) Cream Topical Universal Cosmetic Co., Ltd 2010-08-19 Not applicable US Madecassol Centella asiatica (10 mg/1g) + Neomycin sulfate (3.5 mg/1g) Ointment Topical I World Pharmaceutical Co., Ltd. 2019-10-08 Not applicable US Madecassol Centella asiatica (10 mg/1g) + Neomycin sulfate (3.5 mg/1g) Ointment Topical LYDIA Co., Ltd 2019-10-08 Not applicable US Madecassol Centella asiatica (10 mg/1g) + Neomycin sulfate (3.5 mg/1g) Ointment Topical OASIS TRADING 2018-11-15 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Ato Standard Intensivecream Centella asiatica (0.003 g/100g) + Ceramide NP (0.0006 g/100g) + Macadamia oil (2 g/100g) + Panthenol (0.75 g/100g) Cream Topical TIMEBIO Co., Ltd 2020-12-03 Not applicable US Ato Standard Premium Mildcream Centella asiatica (0.005 g/100g) + Ceramide NP (0.0018 g/100g) + Shea butter (3 g/100g) Cream Topical TIMEBIO Co., Ltd 2021-02-01 Not applicable US Centella 65 Green Tea Pack Centella asiatica (65 g/100g) + Green tea leaf (1 g/100g) Cream Topical Ami Cosmetic Co.,Ltd. 2016-02-23 2019-03-28 US Centellaca A Clear Relaxing Toner Centella asiatica (55.45 mg/100mL) Liquid Topical Wow Ventures 2015-05-01 2017-07-15 US Dr.Different CICA Metal Calming Pad Centella asiatica (0.045 g/90mL) + Madecassoside (0.009 g/90mL) Liquid Topical Dareun Cosmetics Co., Ltd. 2021-09-01 Not applicable US DRH Ultimate Calming Mask Serum Centella asiatica (0.28 g/28g) + Chamaemelum nobile flower (0.02 g/28g) + Purslane (0.28 g/28g) Patch Topical New & New Co.,ltd. 2016-10-01 2018-12-01 US Elcure Curekin Centella asiatica (3000 mg/300mL) Shampoo Topical Elcure Co., Ltd. 2013-07-18 2017-04-20 US INCORD Disposable Feminine Cleansing Centella asiatica (0.09 g/100g) + Propolis wax (0.001 g/100g) + Tea tree oil (0.001 g/100g) Gel Vaginal Hucordbio Co., Ltd. 2022-04-01 Not applicable US LANBELLE Cleansing Centella asiatica (0.01 g/100mL) Gel Topical Tamlatamanu Inc. 2018-03-27 Not applicable US Laser Rejuvenation restoring damage skin Centella asiatica (0.001 mL/1mL) + Acetyl hexapeptide-3 (0.0001 mL/1mL) + Adenosine (0.00004 mL/1mL) Cream Topical Universal Cosmetic Co., Ltd 2010-08-19 Not applicable US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 4YS74Q4G4J
- CAS number
- Not Available
References
- General References
- Not Available
- External Links
- 1807125
- Wikipedia
- Centella_asiatica
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Active Not Recruiting Treatment Dry Skin / Type 2 Diabetes Mellitus 1 2 Completed Treatment Diabetic Neuropathies 1 1 Completed Treatment Gingival Diseases 1 0 Active Not Recruiting Screening Elderly / Healthy Subjects (HS) 1 0 Completed Treatment To Prevent Scar Formation for Patients Underwent Surgery 1 0 Enrolling by Invitation Treatment Promotion of wound healing 1 0 Terminated Screening Cognitive Impairment (CI) / Elderly 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Liquid Topical 55.45 mg/100mL Tablet Oral Spray; tincture Topical 89.5 % Patch Topical Shampoo Topical 3000 mg/300mL Gel Vaginal Gel Topical 0.01 g/100mL Cream Topical Ointment Topical Ointment Gel Vaginal 15 g/100mL Cream Topical 0.3 mg/31 Liquid Topical 0.30 g/100mL Liquid Topical Liquid Topical 0.01 g/100g Cream Topical 0.001 g/100g Gel Topical 0.1 g/100mL - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created at July 05, 2018 17:13 / Updated at June 22, 2021 18:16