Centella asiatica

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Centella asiatica
DrugBank Accession Number
DB14256
Background

Centella asiatica is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Type
Biotech
Groups
Approved, Experimental, Investigational
Synonyms
  • Asiatic Pennywort Whole
  • Bacopa Monniera Whole Extract
  • Bacopa Whole
  • Brahmi Whole
  • Centella Asiatica Extract
  • Coastal Water-hyssop Whole
  • Gotu Kola
  • Gotu Kola Whole
  • Herba Centellae
  • Hydrocotyle
  • Hydrocotyle Asiatica
  • Indian Pennywort Whole
  • Ji Xue Cao Whole
  • Jixuecao Whole
  • Luo De Da Whole
  • Ma Ti Cao Whole
  • Mandukaparni Whole
  • Sheep-rot Whole
  • Spadeleaf Whole
  • Thankuni Whole
  • Water Hyssop Whole

Pharmacology

Indication

Not Available

Pharmacology
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Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe therapeutic efficacy of Acetazolamide can be decreased when used in combination with Centella asiatica.
AmifampridineThe risk or severity of seizure can be increased when Centella asiatica is combined with Amifampridine.
AmobarbitalThe therapeutic efficacy of Amobarbital can be decreased when used in combination with Centella asiatica.
BrexanoloneThe therapeutic efficacy of Brexanolone can be decreased when used in combination with Centella asiatica.
BrivaracetamThe therapeutic efficacy of Brivaracetam can be decreased when used in combination with Centella asiatica.
BupropionThe risk or severity of seizure can be increased when Bupropion is combined with Centella asiatica.
ButalbitalThe therapeutic efficacy of Butalbital can be decreased when used in combination with Centella asiatica.
CannabidiolThe therapeutic efficacy of Cannabidiol can be decreased when used in combination with Centella asiatica.
CarbamazepineThe therapeutic efficacy of Carbamazepine can be decreased when used in combination with Centella asiatica.
CenobamateThe therapeutic efficacy of Cenobamate can be decreased when used in combination with Centella asiatica.
Interactions
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Food Interactions
  • Take with food.

Products

Products2
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dosage, form, labeller, route of administration, and marketing period.
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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Centellaca A Clear Relaxing TonerLiquid55.45 mg/100mLTopicalWow Ventures2015-05-012017-07-15US flag
Cothilyne- Asp-tct 89.5Spray; Tincture89.5 %TopicalHaemacure Corporation1995-12-311999-10-05Canada flag
Elcure CurekinShampoo3000 mg/300mLTopicalElcure Co., Ltd.2013-07-182017-04-20US flag
LANBELLE CleansingGel0.01 g/100mLTopicalTamlatamanu Inc.2018-03-27Not applicableUS flag
Shynomore LubricantGel15 g/100mLVaginalBluette Co., Ltd.2018-01-01Not applicableUS flag
StemCell TeN 10 Revolutionary skin theraphyCream0.3 mg/31TopicalDr.Gene Co.,Ltd2015-04-01Not applicableUS flag
Troiareuke Acsen Toc TonerLiquid0.30 g/100mLTopicalMk Universal Inc.2018-05-012018-12-01US flag
W.skin Natural Fermented Grain Mask SheetLiquid0.01 g/100gTopicalJ&J COMPANY2021-05-08Not applicableUS flag
W.skin Stop-aging Son Joo Rum Handcream PlusCream0.001 g/100gTopicalJ&J COMPANY2021-05-08Not applicableUS flag
Xoul Pure Recovery peelingGel0.1 g/100mLTopicalPicostech Co.,Ltd.2018-03-262018-06-26US flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Centella 65 Green Tea PackCentella asiatica (65 g/100g) + Green tea leaf (1 g/100g)CreamTopicalAmi Cosmetic Co.,Ltd.2016-02-232019-03-28US flag
Dr.Different CICA Metal Calming PadCentella asiatica (0.045 g/90mL) + Madecassoside (0.009 g/90mL)LiquidTopicalDareun Cosmetics Co., Ltd.2021-09-01Not applicableUS flag
DRH Ultimate Calming Mask SerumCentella asiatica (0.28 g/28g) + Chamaemelum nobile flower (0.02 g/28g) + Purslane (0.28 g/28g)PatchTopicalNew & New Co.,ltd.2016-10-012018-12-01US flag
Laser Rejuvenation restoring damage skinCentella asiatica (0.001 mL/1mL) + Acetyl hexapeptide-3 (0.0001 mL/1mL) + Adenosine (0.00004 mL/1mL)CreamTopicalUniversal Cosmetic Co., Ltd2010-08-19Not applicableUS flag
MadecassolCentella asiatica (10 mg/1g) + Neomycin sulfate (3.5 mg/1g)OintmentTopicalOASIS TRADING2018-11-15Not applicableUS flag
MadecassolCentella asiatica (10 mg/1g) + Neomycin sulfate (3.5 mg/1g)OintmentTopicalI World Pharmaceutical Co., Ltd.2019-10-08Not applicableUS flag
MadecassolCentella asiatica (10 mg/1g) + Neomycin sulfate (3.5 mg/1g)OintmentTopicalLYDIA Co., Ltd2019-10-08Not applicableUS flag
No-SCAR Oint.Centella asiatica (10 mg/10g) + Hydrocortisone acetate (10 mg/10g) + Neomycin sulfate (3.5 mg/10g)OintmentTopicalCho-A Pharm.Co.,Ltd.2019-02-22Not applicableUS flag
Varecell Intensive Liposome BoosterCentella asiatica (89.53 g/100mL) + Adenosine (0.04 g/100mL) + Nicotinamide (2 g/100mL)LiquidTopicalD&S Cosmedique Co.Ltd2021-09-06Not applicableUS flag
Varecell Intensive Liposome SerumCentella asiatica (0.1 g/100mL) + 1,2-Hexanediol (3 g/100mL) + Tremella fuciformis whole (0.2 g/100mL)LiquidTopicalD&S Cosmedique Co.Ltd2021-09-02Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Centella 65 Green Tea PackCentella asiatica (65 g/100g) + Green tea leaf (1 g/100g)CreamTopicalAmi Cosmetic Co.,Ltd.2016-02-232019-03-28US flag
Centellaca A Clear Relaxing TonerCentella asiatica (55.45 mg/100mL)LiquidTopicalWow Ventures2015-05-012017-07-15US flag
Dr.Different CICA Metal Calming PadCentella asiatica (0.045 g/90mL) + Madecassoside (0.009 g/90mL)LiquidTopicalDareun Cosmetics Co., Ltd.2021-09-01Not applicableUS flag
DRH Ultimate Calming Mask SerumCentella asiatica (0.28 g/28g) + Chamaemelum nobile flower (0.02 g/28g) + Purslane (0.28 g/28g)PatchTopicalNew & New Co.,ltd.2016-10-012018-12-01US flag
Elcure CurekinCentella asiatica (3000 mg/300mL)ShampooTopicalElcure Co., Ltd.2013-07-182017-04-20US flag
LANBELLE CleansingCentella asiatica (0.01 g/100mL)GelTopicalTamlatamanu Inc.2018-03-27Not applicableUS flag
Laser Rejuvenation restoring damage skinCentella asiatica (0.001 mL/1mL) + Acetyl hexapeptide-3 (0.0001 mL/1mL) + Adenosine (0.00004 mL/1mL)CreamTopicalUniversal Cosmetic Co., Ltd2010-08-19Not applicableUS flag
MadecassolCentella asiatica (10 mg/1g) + Neomycin sulfate (3.5 mg/1g)OintmentTopicalOASIS TRADING2018-11-15Not applicableUS flag
MadecassolCentella asiatica (10 mg/1g) + Neomycin sulfate (3.5 mg/1g)OintmentTopicalI World Pharmaceutical Co., Ltd.2019-10-08Not applicableUS flag
MadecassolCentella asiatica (10 mg/1g) + Neomycin sulfate (3.5 mg/1g)OintmentTopicalLYDIA Co., Ltd2019-10-08Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
7M867G6T1U
CAS number
Not Available

References

General References
Not Available
RxNav
1807125
Wikipedia
Centella_asiatica

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Active Not RecruitingTreatmentDry Skin / Type 2 Diabetes Mellitus1
2CompletedTreatmentDiabetic Neuropathies1
1CompletedTreatmentGingival Diseases1
0Active Not RecruitingScreeningElderly / Healthy Subjects (HS)1
0CompletedTreatmentTo Prevent Scar Formation for Patients Underwent Surgery1
0Enrolling by InvitationTreatmentWound Healing1
0TerminatedScreeningCognitive Impairment (CI) / Elderly1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
LiquidTopical55.45 mg/100mL
TabletOral
Spray; tinctureTopical89.5 %
PatchTopical
ShampooTopical3000 mg/300mL
GelTopical0.01 g/100mL
CreamTopical
OintmentTopical
Ointment
GelVaginal15 g/100mL
CreamTopical0.3 mg/31
LiquidTopical0.30 g/100mL
LiquidTopical
LiquidTopical0.01 g/100g
CreamTopical0.001 g/100g
GelTopical0.1 g/100mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created on July 05, 2018 17:13 / Updated on June 22, 2021 18:16