Interstitial collagenase

BE0000920ProteinHumansMMP1

Cleaves collagens of types I, II, and III at one site in the helical domain. It is acted on by 17 drugs in DrugBank.

Gene name
MMP1
UniProtKB entry
P03956Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix
Residues / weight
469 residues · 54,007 Da
Also known as
3.4.24.7 · CLG · Fibroblast collagenase · Matrix metalloproteinase-1 · MMP-1

Resolves to

Protein
UniProtP03956UniProt nameMMP1_HUMAN
Gene
HGNCHGNC:7155NCBI Gene4312GenBank30126GeneCardsMMP1
Pharmacology
IUPHAR/GtoPdb1628KEGGhsa:4312
Structure
PDB1AYKPDB1CGEPDB1CGF
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
5GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
71+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Interstitial collagenase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In