Influenza A virus A/Texas/50/2012 X-223A (H3N2) antigen (formaldehyde inactivated)

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Influenza A virus A/Texas/50/2012 X-223A (H3N2) antigen (formaldehyde inactivated)
DrugBank Accession Number
DB14452
Background

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen". This defence includes the production of humoral immunity through the development of antibodies (through memory B cells) and of cell-mediated immunity through the production of T-lymphocytes. Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy the virus as there are circulating antibodies that recognize that particular component of the virus that it was previously exposed to.

There are two basic types of vaccines available: inactivated influenza vaccine (IIV) and live attenuated influenza vaccine (LAIV). Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3. Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals. In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated, or weakened, through various laboratory techniques. Live vaccines maintain their replicative ability.

Type
Biotech
Groups
Approved
Biologic Classification
Vaccines
Inactivated
Synonyms
Not Available

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Active Moieties
NameKindUNIICASInChI Key
Influenza A virus A/Texas/50/2012 X-223A (H3N2) hemagglutinin antigen (formaldehyde inactivated)hemagglutininS477VIE5TZNot AvailableNot applicable
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Fluarix 2013/2014Influenza A virus A/Texas/50/2012 X-223A (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Christchurch/16/2010 NIB-74XP (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Massachusetts/2/2012 BX-51B antigen (formaldehyde inactivated) (15 ug/0.5mL)SuspensionIntramuscularGlaxosmithkline Biologicals S.A.2013-07-012013-05-31US flag
Fluarix 2014/2015Influenza A virus A/Texas/50/2012 X-223A (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Christchurch/16/2010 NIB-74XP (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Massachusetts/2/2012 BX-51B antigen (formaldehyde inactivated) (15 ug/0.5mL)SuspensionIntramuscularGlaxosmithkline Biologicals S.A.2014-06-272014-06-27US flag
Fluarix Quadrivalent 2013/2014Influenza A virus A/Texas/50/2012 X-223A (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Christchurch/16/2010 NIB-74XP (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Brisbane/60/2008 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Massachusetts/2/2012 BX-51B antigen (formaldehyde inactivated) (15 ug/0.5mL)SuspensionIntramuscularGlaxosmithkline Biologicals S.A.2013-07-012013-05-31US flag
Fluarix Quadrivalent 2014/2015Influenza A virus A/Texas/50/2012 X-223A (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Christchurch/16/2010 NIB-74XP (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Brisbane/60/2008 antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Massachusetts/2/2012 BX-51B antigen (formaldehyde inactivated) (15 ug/0.5mL)SuspensionIntramuscularGlaxosmithkline Biologicals S.A.2014-07-012014-06-27US flag
FluzoneInfluenza A virus A/Texas/50/2012 X-223A (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/California/7/2009 X-179A (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Massachusetts/2/2012 antigen (formaldehyde inactivated) (15 ug/0.5mL)Injection, suspensionIntramuscularSanofi Pasteur Inc.2013-06-282014-06-30US flag

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
4127F11825
CAS number
Not Available

References

General References
Not Available
Not Available

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
Not AvailableRecruitingNot AvailableChronic Lymphocytic Leukemia / Coronavirus Disease 2019 (COVID‑19) / Diffuse Large B-Cell Lymphoma (DLBCL) / Follicular Lymphoma ( FL) / Mantle Cell Lymphoma (MCL) / Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma1somestatusstop reasonjust information to hide
4CompletedOtherFlu caused by Influenza1somestatusstop reasonjust information to hide
4CompletedOtherHealthy Volunteers (HV) / Influenza immunization2somestatusstop reasonjust information to hide
4CompletedPreventionFlu caused by Influenza6somestatusstop reasonjust information to hide
4CompletedPreventionInfluenza, Human1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SuspensionIntramuscular
Injection, suspensionIntradermal
Injection, suspensionIntramuscular
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at July 05, 2018 18:03 / Updated at June 12, 2020 16:53