Influenza A virus A/Singapore/INFIMH-16-0019/2016 IVR-186 (H3N2) antigen (formaldehyde inactivated)

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Influenza A virus A/Singapore/INFIMH-16-0019/2016 IVR-186 (H3N2) antigen (formaldehyde inactivated) is an inactivated antigen of influenza used in seasonal influenza vaccines.

Brand Names
Fluzone High-dose, Fluzone Quadrivalent
Generic Name
Influenza A virus A/Singapore/INFIMH-16-0019/2016 IVR-186 (H3N2) antigen (formaldehyde inactivated)
DrugBank Accession Number
DB14587
Background

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen". This defence includes the production of humoral immunity through the development of antibodies (through memory B cells) and of cell-mediated immunity through the production of T-lymphocytes. Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy the virus as there are circulating antibodies that recognize that particular component of the virus that it was previously exposed to.

There are two basic types of vaccines available: inactivated influenza vaccine (IIV) and live attenuated influenza vaccine (LAIV). Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3. Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals. In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated, or weakened, through various laboratory techniques. Live vaccines maintain their replicative ability.

Type
Biotech
Groups
Approved
Biologic Classification
Vaccines
Inactivated
Synonyms
Not Available

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
EFLUELDAInfluenza A virus A/Singapore/INFIMH-16-0019/2016 IVR-186 (H3N2) antigen (formaldehyde inactivated) (60 MCG) + Influenza A virus A/Michigan/45/2015 X-275 (H1N1) hemagglutinin antigen (formaldehyde inactivated) (60 MCG) + Influenza B virus B/Maryland/15/2016 BX-69A antigen (formaldehyde inactivated) (60 MCG) + Influenza B virus B/Phuket/3073/2013 hemagglutinin antigen (formaldehyde inactivated) (60 MCG)Injection, suspensionIntramuscular; SubcutaneousSanofi Pasteur Inc.2020-05-26Not applicableItaly flag
EFLUELDAInfluenza A virus A/Singapore/INFIMH-16-0019/2016 IVR-186 (H3N2) antigen (formaldehyde inactivated) (60 MCG) + Influenza A virus A/Michigan/45/2015 X-275 (H1N1) hemagglutinin antigen (formaldehyde inactivated) (60 MCG) + Influenza B virus B/Maryland/15/2016 BX-69A antigen (formaldehyde inactivated) (60 MCG) + Influenza B virus B/Phuket/3073/2013 hemagglutinin antigen (formaldehyde inactivated) (60 MCG)Injection, suspensionIntramuscular; SubcutaneousSanofi Pasteur Inc.2020-05-26Not applicableItaly flag
EFLUELDAInfluenza A virus A/Singapore/INFIMH-16-0019/2016 IVR-186 (H3N2) antigen (formaldehyde inactivated) (60 MCG) + Influenza A virus A/Michigan/45/2015 X-275 (H1N1) hemagglutinin antigen (formaldehyde inactivated) (60 MCG) + Influenza B virus B/Maryland/15/2016 BX-69A antigen (formaldehyde inactivated) (60 MCG) + Influenza B virus B/Phuket/3073/2013 hemagglutinin antigen (formaldehyde inactivated) (60 MCG)Injection, suspensionIntramuscular; SubcutaneousSanofi Pasteur Inc.2020-05-26Not applicableItaly flag
Efluelda Tetra Injektionssuspension in einer FertigspritzeInfluenza A virus A/Singapore/INFIMH-16-0019/2016 IVR-186 (H3N2) antigen (formaldehyde inactivated) (60 mcg) + Influenza A virus A/Michigan/45/2015 X-275 (H1N1) hemagglutinin antigen (formaldehyde inactivated) (60 mcg) + Influenza B virus B/Maryland/15/2016 BX-69A antigen (formaldehyde inactivated) (60 mcg) + Influenza B virus B/Phuket/3073/2013 hemagglutinin antigen (formaldehyde inactivated) (60 mcg)Injection, suspensionIntramuscularSanofi Pasteur Inc.2020-05-07Not applicableAustria flag
FluadInfluenza A virus A/Singapore/INFIMH-16-0019/2016 IVR-186 (H3N2) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza A virus A/Singapore/gp1908/2015 IVR-180 (H1N1) antigen (formaldehyde inactivated) (15 ug/0.5mL) + Influenza B virus B/Maryland/15/2016 antigen (formaldehyde inactivated) (15 ug/0.5mL)Injection, suspensionIntramuscularSeqirus S.R.L.2018-07-132019-07-31US flag

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
KMO6TK08J4
CAS number
Not Available

References

General References
  1. NPRA: SKYCellflu Trivalent (Influenza A virus A/Michigan/45/2015 X-275, Influenza A virus A/Singapore/INFIMH-16-0019/2016 IVR-186, Influenza B virus B/Maryland/15/2016) Intramuscular Injection [Link]
Not Available

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
Not AvailableCompletedNot AvailableInfluenza (Healthy Volunteers)2somestatusstop reasonjust information to hide
Not AvailableCompletedNot AvailableInfluenza Immunization (Healthy Volunteers)1somestatusstop reasonjust information to hide
4CompletedBasic ScienceVaccine Reaction1somestatusstop reasonjust information to hide
3CompletedPreventionInfluenza (Healthy Volunteers)1somestatusstop reasonjust information to hide
3TerminatedPreventionInfluenza (Healthy Volunteers)1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, suspensionIntramuscular; Subcutaneous
Injection, suspensionIntramuscular
Injection, solutionIntramuscular
Injection, suspension
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at August 19, 2018 21:04 / Updated at May 14, 2021 01:06