D-chiro-Inositol

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
D-chiro-Inositol
DrugBank Accession Number
DB15350
Background

D-chiro-Inositol is under investigation in clinical trial NCT03201601 (Evaluation of the Mixture Myoinositol:D-chiro-inositol 3.6:1 in Women With Polycystic Ovary Syndrome).

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 180.1559
Monoisotopic: 180.063388116
Chemical Formula
C6H12O6
Synonyms
  • D-Inositol

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
6R79WV4R10
CAS number
643-12-9
InChI Key
CDAISMWEOUEBRE-SHFUYGGZSA-N
InChI
InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4-,5+,6+/m1/s1
IUPAC Name
(1R,2R,3R,4R,5S,6S)-cyclohexane-1,2,3,4,5,6-hexol
SMILES
O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@H]1O

References

General References
Not Available
Human Metabolome Database
HMDB0240209
ChemSpider
10199754
ChEBI
27374
ChEMBL
CHEMBL3976780
ZINC
ZINC000100024490
Wikipedia
1D-chiro-Inositol

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2, 3CompletedTreatmentInfertility / Polycystic Ovarian Syndrome (PCOS)1
Not AvailableCompletedNot AvailableFertility Disorders / Hodgkin's Lymphoma / Menstrual Irregularities1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility485.0 mg/mLALOGPS
logP-2.6ALOGPS
logP-3.8Chemaxon
logS0.43ALOGPS
pKa (Strongest Acidic)12.29Chemaxon
pKa (Strongest Basic)-3.6Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count6Chemaxon
Polar Surface Area121.38 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity35.78 m3·mol-1Chemaxon
Polarizability15.95 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - GC-MSGC-MSsplash10-014i-0359000000-cec32f7b73a366b3f067
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-0900000000-4edbcc2408024c840f23
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-0900000000-c9ed2f168bddfa69a68f
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0adr-9200000000-6ad6646eaa09bc48b9bb
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-01ox-9100000000-d62e42ea3077a2368e58
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0006-9100000000-3e48cf11430dc0843ce7
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4l-9000000000-809086233c9ccc99a99a
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-137.4266761
predicted
DarkChem Lite v0.1.0
[M-H]-141.51363
predicted
DeepCCS 1.0 (2019)
[M+H]+139.8723761
predicted
DarkChem Lite v0.1.0
[M+H]+143.9092
predicted
DeepCCS 1.0 (2019)
[M+Na]+137.3780761
predicted
DarkChem Lite v0.1.0
[M+Na]+150.49464
predicted
DeepCCS 1.0 (2019)

Drug created at May 20, 2019 15:18 / Updated at June 12, 2020 16:53