Aromatase

BE0002090ProteinHumansCYP19A1

A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively (PubMed:27702664, PubMed:2848247). It is acted on by 75 drugs in DrugBank.

Gene name
CYP19A1
UniProtKB entry
P11511Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
503 residues · 57,882 Da
Also known as
1.14.14.14 · ARO1 · CYAR · CYP19 · CYPXIX

Resolves to

Protein
UniProtP11511UniProt nameCP19A_HUMAN
Gene
HGNCHGNC:2594NCBI Gene1588GenBank179002GeneCardsCYP19A1
Pharmacology
IUPHAR/GtoPdb1362KEGGhsa:1588
Structure
PDB3EQMPDB3S79PDB3S7S
Drugs

What you can answer from here — as of September 03, 2024

75DrugsApproved to experimental, with action, bond type and pharmacological action
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79Clinical trialsTrials of drugs acting on it, by phase and status
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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184+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aromatase, how selective are they, and which programs against it are still in active trials?

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