Natural killer (NK) cells can be incubated with ‘feeder cells’ expressing certain cytokines prior to maturation to enhance their activity. In particular, incubation with IL-15 allows NK cells to lyse... In particular, incubation with IL-15 allows NK cells to lyse a broad range of fresh and cultured tumor targets that the cell is not normally sensitive to.
- Mechanism
- Curator reviewed
IL-15 is a key cytokine in NK cell development and function; the IL-15 receptor (IL-15R) is constitutively expressed in both the CD56bright and CD56dim matured NK cells. Activation of the IL-15R involves 3 downstream pathways: JAK1/3/STAT3/5, P13K/Akt/mTOR, and Ras/Raf/MEK/ERK. It was shown that ‘priming’ NK-cells with IL-15 markedly enhanced anti-tumor responses which included cytotoxicity, degranulation, and cytokine production.
- Also known as
- IL15-Natural Killer Cell
- Code names
- IL15-NK cells
Resolves to
What you can answer from here — as of July 08, 2026
Which drugs share a target with IL15-NK Cell, and which of those have an active Phase 3 trial?
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