NAV

Tulrampator

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Tulrampator
DrugBank Accession Number
DB16344
Background

Tulrampator is under investigation in clinical trial NCT02626572 (Efficacy and Safety of 3 Doses of S47445 Versus Placebo in Patients With Alzheimer's Disease at Mild to Moderate Stages With Depressive Symptoms).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 380.379
Monoisotopic: 380.128468586
Chemical Formula
C20H17FN4O3
Synonyms
  • Tulrampator
External IDs
  • CX1632
  • S47445
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
7633T9D4LN
CAS number
1038984-31-4
InChI Key
JHCFQXNWYDLBOG-UHFFFAOYSA-N
InChI
InChI=1S/C20H17FN4O3/c21-13-3-1-2-12(8-13)6-7-25-20(27)15-10-18-16(9-17(15)22-23-25)19(26)24(11-28-18)14-4-5-14/h1-3,8-10,14H,4-7,11H2
IUPAC Name
13-cyclopropyl-6-[2-(3-fluorophenyl)ethyl]-11-oxa-4,5,6,13-tetraazatricyclo[8.4.0.0^{3,8}]tetradeca-1(10),2,4,8-tetraene-7,14-dione
SMILES
FC1=CC=CC(CCN2N=NC3=CC4=C(OCN(C5CC5)C4=O)C=C3C2=O)=C1

References

General References
Not Available
ChemSpider
26354919
ChEMBL
CHEMBL1276826
ZINC
ZINC000064447868
Wikipedia
Tulrampator

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentAlzheimer's Disease (AD)1
2CompletedTreatmentMajor Depressive Disorder (MDD)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0201 mg/mLALOGPS
logP2.91ALOGPS
logP3.71Chemaxon
logS-4.3ALOGPS
pKa (Strongest Basic)-2.3Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area74.57 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity103.05 m3·mol-1Chemaxon
Polarizability38.51 Å3Chemaxon
Number of Rings5Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-0009000000-89e7d7e25c7d76ba7709
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0pdi-0139000000-baf97d8538b8ca49e139
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-0019000000-58edb95a55ec84800f40
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-000b-0589000000-c83635cb36b58a92e260
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-066r-0397000000-506736be5c3c78c54b66
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-000i-2794000000-bc25b5407897ad63456a
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at December 15, 2020 20:03 / Updated at February 21, 2021 18:55