PBR-06 F-18
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- PBR-06 F-18
- DrugBank Accession Number
- DB17020
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 394.433
Monoisotopic: 394.155820859 - Chemical Formula
- C23H22FNO4
- Synonyms
- Acetamide, n-((2,5-dimethoxyphenyl)methyl)-2-(fluoro-18f)-n-(2-phenoxyphenyl)-
- External IDs
- (18F)FBR
- (18F)PBR06
- FBR F-18
- PBR-06 F-18
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 41TIZ5663Z
- CAS number
- 1003581-94-9
- InChI Key
- NSOMTOOLHNHIJA-MIGPCILRSA-N
- InChI
- InChI=1S/C23H22FNO4/c1-27-19-12-13-21(28-2)17(14-19)16-25(23(26)15-24)20-10-6-7-11-22(20)29-18-8-4-3-5-9-18/h3-14H,15-16H2,1-2H3/i24-1
- IUPAC Name
- N-[(2,5-dimethoxyphenyl)methyl]-2-(¹⁸F)fluoro-N-(2-phenoxyphenyl)acetamide
- SMILES
- COC1=CC=C(OC)C(CN(C(=O)C[18F])C2=CC=CC=C2OC2=CC=CC=C2)=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 9871593
- ChEMBL
- CHEMBL480193
- ZINC
- ZINC000101621887
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 0 Completed Treatment Multiple System Atrophy (MSA) / Multiple System Atrophy (MSA) With Orthostatic Hypotension / Multiple System Atrophy, Cerebellar Variant (Disorder) / Multiple System Atrophy, Parkinson Variant (Disorder) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0021 mg/mL ALOGPS logP 4.34 ALOGPS logP 4.06 Chemaxon logS -5.3 ALOGPS pKa (Strongest Acidic) 14.5 Chemaxon pKa (Strongest Basic) -3.7 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 48 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 107.83 m3·mol-1 Chemaxon Polarizability 39.73 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at September 29, 2022 22:21 / Updated at December 01, 2022 11:33