TPCA-1

DB17058ExperimentalSmall molecule

TPCA-1 is a selective inhibitor of human IκB kinase 2 (IKK-2).

Mechanism: Pharmacologically active on Inhibitor of nuclear factor kappa-B kinase subunit beta and Signal transducer and activator of transcription 3
Curator reviewed
Formula / weight: C₁₂H₁₀FN₃O₂S · 279.29 g/mol (avg)
Also known as: 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide · 3-thiophenecarboxamide, 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)- · Ikk 2 inhibitor iv · Ikk-2 inhibitor iv
Code names: TPCA-1

Resolves to

Compound

Structure

InChIKeySAYGKHKXGCPTLX-UHFFFAOYSA-NSMILESNC(=O)NC1=C(C=C(S1)C1=CC=C(F)C=C1)C(N)=O

Targets

What you can answer from here — as of July 08, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with TPCA-1, and which of those have an active Phase 3 trial?

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