Signal transducer and activator of transcription 3

Details

Name
Signal transducer and activator of transcription 3
Kind
protein
Synonyms
  • Acute-phase response factor
  • APRF
Gene Name
STAT3
UniProtKB Entry
P40763Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0006733|Signal transducer and activator of transcription 3
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
Number of residues
770
Molecular Weight
88067.215
Theoretical pI
6.23
GO Classification
Functions
DNA binding / protein dimerization activity / protein kinase binding / protein phosphatase binding
Processes
astrocyte differentiation / cellular response to hormone stimulus / cytokine-mediated signaling pathway / eating behavior / eye photoreceptor cell differentiation / glucose homeostasis / growth hormone receptor signaling pathway / interleukin-6-mediated signaling pathway / intracellular receptor signaling pathway / negative regulation of glycolytic process / negative regulation of neuron migration / nervous system development / phosphorylation / positive regulation of Notch signaling pathway / protein import into nucleus / radial glial cell differentiation / regulation of multicellular organism growth / response to estradiol / sexual reproduction / signal transduction / somatic stem cell population maintenance / temperature homeostasis
Components
cytoplasm / cytosol / nucleoplasm / nucleus / plasma membrane
General Function
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18242580, PubMed:18782771, PubMed:22306293, PubMed:23084476, PubMed:28262505, PubMed:32929201). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18782771, PubMed:28262505, PubMed:32929201). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation (PubMed:28065600, PubMed:28262505). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity)
Specific Function
chromatin DNA binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0017109|Signal transducer and activator of transcription 3 (STAT3)
ATGGCCCAATGGAATCAGCTACAGCAGCTTGACACACGGTACCTGGAGCAGCTCCATCAG
CTCTACAGTGACAGCTTCCCAATGGAGCTGCGGCAGTTTCTGGCCCCTTGGATTGAGAGT
CAAGATTGGGCATATGCGGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTC
CTGGGAGAGATTGACCAGCAGTATAGCCGCTTCCTGCAAGAGTCGAATGTTCTCTATCAG
CACAATCTACGAAGAATCAAGCAGTTTCTTCAGAGCAGGTATCTTGAGAAGCCAATGGAG
ATTGCCCGGATTGTGGCCCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAGCC
ACTGCGGCCCAGCAAGGGGGCCAGGCCAACCACCCCACAGCAGCCGTGGTGACGGAGAAG
CAGCAGATGCTGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTGCAGGATCTAGAACAG
AAAATGAAAGTGGTAGAGAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAG
AGTCAAGGAGACATGCAAGATCTGAATGGAAACAACCAGTCAGTGACCAGGCAGAAGATG
CAGCAGCTGGAACAGATGCTCACTGCGCTGGACCAGATGCGGAGAAGCATCGTGAGTGAG
CTGGCGGGGCTTTTGTCAGCGATGGAGTACGTGCAGAAAACTCTCACGGACGAGGAGCTG
GCTGACTGGAAGAGGCGGCAACAGATTGCCTGCATTGGAGGCCCGCCCAACATCTGCCTA
GATCGGCTAGAAAACTGGATAACGTCATTAGCAGAATCTCAACTTCAGACCCGTCAACAA
ATTAAGAAACTGGAGGAGTTGCAGCAAAAAGTTTCCTACAAAGGGGACCCCATTGTACAG
CACCGGCCGATGCTGGAGGAGAGAATCGTGGAGCTGTTTAGAAACTTAATGAAAAGTGCC
TTTGTGGTGGAGCGGCAGCCCTGCATGCCCATGCATCCTGACCGGCCCCTCGTCATCAAG
ACCGGCGTCCAGTTCACTACTAAAGTCAGGTTGCTGGTCAAATTCCCTGAGTTGAATTAT
CAGCTTAAAATTAAAGTGTGCATTGACAAAGACTCTGGGGACGTTGCAGCTCTCAGAGGA
TCCCGGAAATTTAACATTCTGGGCACAAACACAAAAGTGATGAACATGGAAGAATCCAAC
AACGGCAGCCTCTCTGCAGAATTCAAACACTTGACCCTGAGGGAGCAGAGATGTGGGAAT
GGGGGCCGAGCCAATTGTGATGCTTCCCTGATTGTGACTGAGGAGCTGCACCTGATCACC
TTTGAGACCGAGGTGTATCACCAAGGCCTCAAGATTGACCTAGAGACCCACTCCTTGCCA
GTTGTGGTGATCTCCAACATCTGTCAGATGCCAAATGCCTGGGCGTCCATCCTGTGGTAC
AACATGCTGACCAACAATCCCAAGAATGTAAACTTTTTTACCAAGCCCCCAATTGGAACC
TGGGATCAAGTGGCCGAGGTCCTGAGCTGGCAGTTCTCCTCCACCACCAAGCGAGGACTG
AGCATCGAGCAGCTGACTACACTGGCAGAGAAACTCTTGGGACCTGGTGTGAATTATTCA
GGGTGTCAGATCACATGGGCTAAATTTTGCAAAGAAAACATGGCTGGCAAGGGCTTCTCC
TTCTGGGTCTGGCTGGACAATATCATTGACCTTGTGAAAAAGTACATCCTGGCCCTTTGG
AACGAAGGGTACATCATGGGCTTTATCAGTAAGGAGCGGGAGCGGGCCATCTTGAGCACT
AAGCCTCCAGGCACCTTCCTGCTAAGATTCAGTGAAAGCAGCAAAGAAGGAGGCGTCACT
TTCACTTGGGTGGAGAAGGACATCAGCGGTAAGACCCAGATCCAGTCCGTGGAACCATAC
ACAAAGCAGCAGCTGAACAACATGTCATTTGCTGAAATCATCATGGGCTATAAGATCATG
GATGCTACCAATATCCTGGTGTCTCCACTGGTCTATCTCTATCCTGACATTCCCAAGGAG
GAGGCATTCGGAAAGTATTGTCGGCCAGAGAGCCAGGAGCATCCTGAAGCTGACCCAGGC
GCTGCCCCATACCTGAAGACCAAGTTTATCTGTGTGACACCAACGACCTGCAGCAATACC
ATTGACCTGCCGATGTCCCCCCGCACTTTAGATTCATTGATGCAGTTTGGAAATAATGGT
GAAGGTGCTGAACCCTCAGCAGGAGGGCAGTTTGAGTCCCTCACCTTTGACATGGAGTTG
ACCTCGGAGTGCGCTACCTCCCCCATGTGA
Chromosome Location
17
Locus
17q21.2
External Identifiers
ResourceLink
UniProtKB IDP40763
UniProtKB Entry NameSTAT3_HUMAN
GenBank Gene IDAF029311
GeneCard IDSTAT3
GenAtlas IDSTAT3
HGNC IDHGNC:11364
PDB ID(s)5AX3, 5U5S, 6NJS, 6NUQ, 6QHD, 6TLC
KEGG IDhsa:6774
IUPHAR/Guide To Pharmacology ID2994
NCBI Gene ID6774
General References
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
ENMD-1198investigationalunknowntargetDetails
OPB-111077investigationalunknowntargetinhibitorDetails
TTI-101investigationalyestargetinhibitorDetails
MOL-4239investigationalyestargetinhibitorDetails
AtiprimodinvestigationalyestargetinhibitorDetails
WP-1066investigationalyestargetinhibitorDetails
NT-219investigationalyestargetinhibitorDetails
GolotimodinvestigationalyestargetinhibitorDetails
NapabucasininvestigationalyestargetinhibitorDetails
AcitretinapprovedyestargetinhibitorDetails
Epigallocatechin gallateinvestigationalyestargetinhibitorDetails
DiosmetinexperimentalyestargetinhibitorDetails
Celecoxibapproved, investigationalyestargetinhibitorDetails
LuteolinexperimentalyestargetinhibitorDetails
Quercetinexperimental, investigationalyestargetinhibitorDetails