Signal transducer and activator of transcription 3

BE0003462ProteinHumansSTAT3

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:11294841, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18242580, PubMed:18782771, PubMed:22306293, PubMed:23084476, PubMed:28262505, PubMed:32929201, PubMed:38404237). It is acted on by 31 drugs in DrugBank.

Gene name
STAT3
UniProtKB entry
P40763Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
770 residues · 88,067 Da
Also known as
Acute-phase response factor · APRF

Resolves to

Protein
UniProtP40763UniProt nameSTAT3_HUMAN
Gene
HGNCHGNC:11364NCBI Gene6774GeneCardsSTAT3
Pharmacology
IUPHAR/GtoPdb2994KEGGhsa:6774
Structure
PDB5AX3PDB5U5SPDB6NJS
Drugs

What you can answer from here — as of September 07, 2019

31DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
32Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
71GO termsFunction, process and component, as structured annotations
Sign in
5Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
99+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Signal transducer and activator of transcription 3, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In