Inhibitor of nuclear factor kappa-B kinase subunit beta

BE0001154ProteinHumansIKBKB

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416,... It is acted on by 22 drugs in DrugBank.

Gene name
IKBKB
UniProtKB entry
O14920Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
756 residues · 86,563 Da
Also known as
2.7.11.10 · I-kappa-B kinase 2 · I-kappa-B-kinase beta · IkBKB · IKK-2

Resolves to

Protein
UniProtO14920UniProt nameIKKB_HUMAN
Gene
HGNCHGNC:5960NCBI Gene3551GenBank2599558GeneCardsIKBKB
Pharmacology
IUPHAR/GtoPdb2039KEGGhsa:3551
Structure
PDB3BRTPDB3BRVPDB4E3C
Drugs

What you can answer from here — as of September 07, 2019

22DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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92+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Inhibitor of nuclear factor kappa-B kinase subunit beta, how selective are they, and which programs against it are still in active trials?

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