TW-37

DB17059ExperimentalSmall molecule

TW-37 is a small-molecule inhibitor of Bcl-2 investigated for its anti-cancer properties.

Formula / weight: C₃₃H₃₅NO₆S · 573.7 g/mol (avg)
Also known as: Benzamide, n-(4-((2-(1,1-dimethylethyl)phenyl)sulfonyl)phenyl)-2,3,4-trihydroxy-5-((2-(1-methylethyl)phenyl)methyl)- · N-(4-((2-(1,1-dimethylethyl)phenyl)sulfonyl)phenyl)-2,3,4-trihydroxy-5-((2-(1-methylethyl)phenyl)methyl)benzamide · N-[4-[[2-(1,1-Dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide
Code names: TW-37

Resolves to

Compound

Structure

InChIKeyPQAPVTKIEGUPRN-UHFFFAOYSA-NSMILESCC(C)C1=CC=CC=C1CC1=C(O)C(O)=C(O)C(=C1)C(=O)NC1=CC=C(C=C1)S(=O)(=O)C1=CC=CC=C1C(C)(C)C

Targets

What you can answer from here — as of March 06, 2025

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

9+ReferencesStructured and connected to the statements they support

Which drugs share a target with TW-37, and which of those have an active Phase 3 trial?

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