Apoptosis regulator Bcl-2

BE0000246ProteinHumansBCL2

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). It is acted on by 31 drugs in DrugBank.

Gene name
BCL2
UniProtKB entry
P10415Swiss-Prot
Cellular location
Mitochondrion outer membrane
Residues / weight
239 residues · 26,266 Da

Resolves to

Protein
UniProtP10415UniProt nameBCL2_HUMAN
Gene
HGNCHGNC:990NCBI Gene596GenBank179367GeneCardsBCL2
Pharmacology
IUPHAR/GtoPdb2844KEGGhsa:596
Structure
PDB1G5MPDB1GJHPDB1YSW
Drugs

What you can answer from here — as of September 07, 2019

31DrugsApproved to experimental, with action, bond type and pharmacological action
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117Clinical trialsTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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117+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Apoptosis regulator Bcl-2, how selective are they, and which programs against it are still in active trials?

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