Apoptosis regulator Bcl-2

Details

Name
Apoptosis regulator Bcl-2
Kind
protein
Synonyms
Not Available
Gene Name
BCL2
UniProtKB Entry
P10415Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0000491|Apoptosis regulator Bcl-2
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
Number of residues
239
Molecular Weight
26265.66
Theoretical pI
7.32
GO Classification
Functions
BH domain binding / DNA-binding transcription factor binding / molecular adaptor activity / protein phosphatase 2A binding
Processes
autophagy / B cell apoptotic process / calcium ion transport into cytosol / cell-cell adhesion / dendritic cell apoptotic process / DNA damage response / epithelial cell apoptotic process / establishment of localization in cell / G1/S transition of mitotic cell cycle / hematopoietic stem cell differentiation / motor neuron apoptotic process / myeloid cell apoptotic process / negative regulation of B cell apoptotic process / negative regulation of dendritic cell apoptotic process / negative regulation of epithelial cell apoptotic process / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / negative regulation of motor neuron apoptotic process / negative regulation of T cell apoptotic process / neuron maturation / osteoblast proliferation / positive regulation of apoptotic process / positive regulation of cell population proliferation / regulation of protein localization / response to xenobiotic stimulus / retinal cell programmed cell death / skeletal muscle fiber development / smooth muscle cell migration / stem cell development / T cell apoptotic process
Components
BAD-BCL-2 complex / protein-containing complex
General Function
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354). Appears to function in a feedback loop system with caspases (PubMed:11368354). Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed:18570871, PubMed:20889974, PubMed:21358617). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785)
Specific Function
BH domain binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
212-233
Cellular Location
Mitochondrion outer membrane
Gene sequence
>lcl|BSEQ0021924|Apoptosis regulator Bcl-2 (BCL2)
ATGGCGCACGCTGGGAGAACAGGGTACGATAACCGGGAGATAGTGATGAAGTACATCCAT
TATAAGCTGTCGCAGAGGGGCTACGAGTGGGATGCGGGAGATGTGGGCGCCGCGCCCCCG
GGGGCCGCCCCCGCACCGGGCATCTTCTCCTCCCAGCCCGGGCACACGCCCCATCCAGCC
GCATCCCGGGACCCGGTCGCCAGGACCTCGCCGCTGCAGACCCCGGCTGCCCCCGGCGCC
GCCGCGGGGCCTGCGCTCAGCCCGGTGCCACCTGTGGTCCACCTGACCCTCCGCCAGGCC
GGCGACGACTTCTCCCGCCGCTACCGCCGCGACTTCGCCGAGATGTCCAGCCAGCTGCAC
CTGACGCCCTTCACCGCGCGGGGACGCTTTGCCACGGTGGTGGAGGAGCTCTTCAGGGAC
GGGGTGAACTGGGGGAGGATTGTGGCCTTCTTTGAGTTCGGTGGGGTCATGTGTGTGGAG
AGCGTCAACCGGGAGATGTCGCCCCTGGTGGACAACATCGCCCTGTGGATGACTGAGTAC
CTGAACCGGCACCTGCACACCTGGATCCAGGATAACGGAGGCTGGGATGCCTTTGTGGAA
CTGTACGGCCCCAGCATGCGGCCTCTGTTTGATTTCTCCTGGCTGTCTCTGAAGACTCTG
CTCAGTTTGGCCCTGGTGGGAGCTTGCATCACCCTGGGTGCCTATCTGGGCCACAAGTGA
Chromosome Location
18
Locus
18q21.33
External Identifiers
ResourceLink
UniProtKB IDP10415
UniProtKB Entry NameBCL2_HUMAN
GenBank Protein ID179367
GenBank Gene IDM13994
GeneCard IDBCL2
GenAtlas IDBCL2
HGNC IDHGNC:990
PDB ID(s)1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN, 5AGW, 5AGX, 5FCG, 5JSN, 5VAU, 5VAX, 5VAY, 6GL8, 6IWB, 6O0K, 6O0L, 6O0M, 6O0O, 6O0P, 7LHB, 7Y90, 7YA5, 8FY1, 8FY2, 8HLL, 8HLM, 8HLN, 8HOG, 8HOH, 8HOI, 8IQL, 8U27
KEGG IDhsa:596
IUPHAR/Guide To Pharmacology ID2844
NCBI Gene ID596
General References
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Paclitaxelapproved, vet_approvedyestargetinhibitorDetails
Docetaxelapproved, investigationalunknowntargetDetails
RasagilineapprovedyestargetactivatorDetails
Paclitaxel docosahexaenoic acidinvestigationalunknowntargetDetails
Eribulinapproved, investigationalunknowntargetDetails
NavitoclaxinvestigationalyestargetinhibitorDetails
ApoptoneinvestigationalunknowntargetDetails
ObatoclaxinvestigationalyestargetinhibitorDetails
IbuprofenapprovedunknowntargetmodulatorDetails
Venetoclaxapproved, investigationalyestargetantagonistinhibitorDetails
Dexibuprofenapproved, investigationalunknowntargetnegative modulatorDetails
Terpinen-4-olinvestigationalunknowntargetregulatorDetails
AN-9investigationalyestargetdownregulatorDetails
Oleandrinexperimental, investigationalunknowntargetdownregulatorDetails
TW-37investigationalyestargetinhibitorDetails
LisaftoclaxinvestigationalyestargetinhibitorDetails
GossypolinvestigationalyestargetregulatorDetails
ThymoquinoneinvestigationalyestargetinhibitorDetails
Oblimersenexperimental, investigationalyestargetinhibitorDetails
Edaravoneapproved, investigationalyestargetupregulatorDetails
ABT-737investigationalyestargetinhibitorDetails