Mitogen-activated protein kinase kinase kinase 2

BE0004745ProteinHumansMAP3K2

Component of a protein kinase signal transduction cascade. It is acted on by 4 drugs in DrugBank.

Gene name
MAP3K2
UniProtKB entry
Q9Y2U5Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
619 residues · 69,740 Da
Also known as
2.7.11.25 · MAPK/ERK kinase kinase 2 · MAPKKK2 · MEK kinase 2 · MEKK 2

Resolves to

Protein
UniProtQ9Y2U5UniProt nameM3K2_HUMAN
Gene
HGNCHGNC:6854NCBI Gene10746GeneCardsMAP3K2
Pharmacology
IUPHAR/GtoPdb2077KEGGhsa:10746
Structure
PDB2CU1PDB2NPTPDB5EX0
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase kinase kinase 2, how selective are they, and which programs against it are still in active trials?

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