Sovleplenib
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Sovleplenib
- DrugBank Accession Number
- DB17557
- Background
Sovleplenib is a novel, investigational, selective small molecule inhibitor for oral administration targeting spleen tyrosine kinase (Syk). It is under investigation in clinical trial NCT03483948 (Phase I Study of Hmpl-523+azacitidine in Elderly Patients With Acute Myeloid Leukemia).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 482.6
Monoisotopic: 482.210010024 - Chemical Formula
- C24H30N6O3S
- Synonyms
- Not Available
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 9CL6353KHO
- CAS number
- 1415792-84-5
- InChI Key
- NJIAKNWTIVDSDA-FQEVSTJZSA-N
- InChI
- InChI=1S/C24H30N6O3S/c1-34(31,32)30-11-6-18(7-12-30)17-2-4-19(5-3-17)21-14-22-23(27-9-8-26-22)24(29-21)28-16-20-15-25-10-13-33-20/h2-5,8-9,14,18,20,25H,6-7,10-13,15-16H2,1H3,(H,28,29)/t20-/m0/s1
- IUPAC Name
- 7-[4-(1-methanesulfonylpiperidin-4-yl)phenyl]-N-{[(2S)-morpholin-2-yl]methyl}pyrido[3,4-b]pyrazin-5-amine
- SMILES
- CS(=O)(=O)N1CCC(CC1)C1=CC=C(C=C1)C1=CC2=NC=CN=C2C(NC[C@@H]2CNCCO2)=N1
References
- General References
- Not Available
- External Links
- ChemSpider
- 115010433
- ZINC
- ZINC000143715528
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Active Not Recruiting Treatment Primary Immune Thrombocytopenia (ITP) 1 2, 3 Active Not Recruiting Treatment Warm Autoimmune Hemolytic Anemia 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0338 mg/mL ALOGPS logP 2.23 ALOGPS logP 0.87 Chemaxon logS -4.2 ALOGPS pKa (Strongest Acidic) 16.12 Chemaxon pKa (Strongest Basic) 8.3 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 8 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 109.34 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 130.62 m3·mol-1 Chemaxon Polarizability 53.49 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at February 16, 2023 00:45 / Updated at February 16, 2023 16:06