Bleximenib

DB19328InvestigationalSmall molecule

Bleximenib is under investigation in clinical trials NCT04811560 (A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia) and NCT05453903 (A Study of Bleximenib in Combination With Acute Myeloid...

Mechanism: Pharmacologically active on Histone-lysine N-methyltransferase 2A and Menin
Curator reviewed
Formula / weight: C₃₂H₅₀FN₇O₃ · 599.796 g/mol (avg)
Also known as: Benzamide, N-ethyl-5-fluoro-2-[[5-[2-[(1R)-4-[(2-methoxyethyl)methylamino]-1-(1-methylethyl)butyl]-2,6-diazaspiro[3.4]oct-6-yl]-1,2,4-triazin-6-yl]oxy]-N-(1-methylethyl)- · N-ethyl-5-fluoro-2-{[5-(2-{(3R)-6-[(2-methoxyethyl)(methyl)amino]-2-methylhexan-3-yl}-2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl]oxy}-N-(propan-2-yl)benzamide
Code names: CS-0636752 · DA-55335 · HY-148669 · JNJ-75276617

Resolves to

Compound

UNIIDCN5WEN78TCAS2654081-35-1ChEMBLCHEMBL5314509

Structure

InChIKeyPDUGAXSIWNMIBQ-HHHXNRCGSA-NSMILESCCN(C(C)C)C(=O)C1=CC(F)=CC=C1OC1=NN=CN=C1N1CCC2(CN(C2)[C@H](CCCN(C)CCOC)C(C)C)C1

Targets

Q03164KMT2AO00255MEN1

What you can answer from here — as of September 16, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

6Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Bleximenib, and which of those have an active Phase 3 trial?

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