Menin

BE0010442ProteinHumansMEN1

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). It is acted on by 6 drugs in DrugBank.

Gene name
MEN1
UniProtKB entry
O00255Swiss-Prot
Cellular location
Nucleus
Residues / weight
610 residues · 67,496 Da
Also known as
SCG2

Resolves to

Protein
UniProtO00255UniProt nameMEN1_HUMAN
Gene
HGNCHGNC:7010NCBI Gene4221GeneCardsMEN1
Pharmacology
KEGGhsa:4221
Structure
PDB3U84PDB3U85PDB3U86
Drugs

What you can answer from here — as of October 31, 2023

6DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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39GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Menin, how selective are they, and which programs against it are still in active trials?

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