BTZ-043
Star0
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- BTZ-043
- DrugBank Accession Number
- DB17737
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 431.39
Monoisotopic: 431.07627629 - Chemical Formula
- C17H16F3N3O5S
- Synonyms
- 2-((2s)-2-methyl-1,4-dioxa-8-azaspiro(4.5)decan-8-yl)-8-nitro-6-trifluoromethyl-4h-1,3-benzothiazin-4-one
- 4h-1,3-benzothiazin-4-one, 2-((2s)-2-methyl-1,4-dioxa-8-azaspiro(4.5)dec-8-yl)-8-nitro-6-(trifluoromethyl)-
- External IDs
- BTZ-043
- BTZ-10526043
- BZT043
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- G55ZH52P57
- CAS number
- 1161233-85-7
- InChI Key
- GTUIRORNXIOHQR-VIFPVBQESA-N
- InChI
- InChI=1S/C17H16F3N3O5S/c1-9-8-27-16(28-9)2-4-22(5-3-16)15-21-14(24)11-6-10(17(18,19)20)7-12(23(25)26)13(11)29-15/h6-7,9H,2-5,8H2,1H3/t9-/m0/s1
- IUPAC Name
- 2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one
- SMILES
- C[C@H]1COC2(CCN(CC2)C2=NC(=O)C3=CC(=CC(=C3S2)[N+]([O-])=O)C(F)(F)F)O1
References
- General References
- Not Available
- External Links
- ChemSpider
- 24747357
- ChEMBL
- CHEMBL1822872
- ZINC
- ZINC000043208590
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Recruiting Other Tuberculosis (TB) 1 2 Recruiting Treatment Other Specified Pulmonary Tuberculosis / Pulmonary Tuberculosis (TB) 2 2 Recruiting Treatment Pulmonary Tuberculosis (TB) 1 1 Completed Treatment Bacterial Infections / Lung Disorder / Mycobacterium Infections / Pulmonary Tuberculosis (TB) / Tuberculosis (TB) 1 1 Completed Treatment Lung Disorder / Mycobacterium Infections / Pulmonary Tuberculosis (TB) / Respiratory Infection Bacterial / Tuberculosis (TB) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 3.65 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 94.27 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 97.15 m3·mol-1 Chemaxon Polarizability 38.93 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at May 02, 2023 22:58 / Updated at May 04, 2023 06:06