AVA-4746

DB18022ExperimentalSmall molecule

AVA-4746: Overview.

Mechanism: Pharmacologically active on Integrin alpha-4 and VLA-4 (very late antigen-4)
Curator reviewed
Formula / weight: C₂₄H₂₄ClN₃O₅ · 469.92 g/mol (avg)
Also known as: (3s)-3-(((1-(2-chlorobenzyl)-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3yl)amino)carbonyl)amino-3-(4-methylphenyl)propanoic acid · Benzenepropanoic acid, .beta.-((((1-((2-chlorophenyl)methyl)-1,2-dihydro-4-hydroxy-5-methyl-2-oxo-3-pyridinyl)amino)carbonyl)amino)-4-methyl-, (.beta.s)-
Code names: AVA-4746

Resolves to

Compound

Structure

InChIKeyJRGSXHUFFDTFCN-IBGZPJMESA-NSMILESCC1=CC=C(C=C1)[C@H](CC(O)=O)NC(=O)NC1=C(O)C(C)=CN(CC2=CC=CC=C2Cl)C1=O

Targets

What you can answer from here — as of September 12, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with AVA-4746, and which of those have an active Phase 3 trial?

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