Zilurgisertib

DB18152ApprovedInvestigationalSmall molecule

Zilurgisertib: Overview.

Chemical structure of Zilurgisertib
Mechanism
Curator reviewed
Formula / weight
C30H38N4O3 · 502.659 g/mol (avg)
First approval
United States, 2026
Code names
INCB-000928 · NBU-928 free base

Resolves to

Compound
UNIIL5Z9S25HO2CAS2173389-57-4ChEMBLCHEMBL5314579ChEBI759277PubChem138628908
Structure
InChIKeyKPRPFTOLWQQUAV-OCVAFRRMSA-NSMILESNC1=NC=C(C=C1C(=O)NC12CCC(O)(CC1)CC2)C1=CC=C(C=C1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1
Targets
Q04771ACVR1

What you can answer from here — as of October 19, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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4Clinical trialsPhase, status and sponsor resolved per trial
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1Structured indicationCondition, population, route and combination as fields, not prose
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1Marketed productAcross 1 country and 1 labeller
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5+ReferencesStructured and connected to the statements they support
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