Rodatristat

DB18478ExperimentalSmall molecule

Rodatristat: Overview.

Mechanism: Pharmacologically active on Tryptophan 5-hydroxylase 1
Curator reviewed
Formula / weight: C₂₇H₂₇ClF₃N₅O₃ · 561.99 g/mol (avg)
Also known as: (3s)-8-(2-amino-6-((1r)-1-(5-chloro(1,1'-biphenyl)-2-yl)-2,2,2-trifluoroethoxy)-4-pyrimidinyl)-2,8-diazaspiro(4.5)decane-3-carboxylic acid · (3s)-8-(2-amino-6-((1r)-1-(5-chloro(1,1'-biphenyl)-2-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro(4.5)decane-3-carboxylic acid · 2,8-diazaspiro(4.5)decane-3-carboxylic acid, 8-(2-amino-6-((1r)-1-(5-chloro(1,1'-biphenyl)-2-yl)-2,2,2-trifluoroethoxy)-4-pyrimidinyl)-, (3s)-
Code names: KAR-5417 · RVT-1201/014

Resolves to

Compound

Structure

InChIKeyZNSPHKJFQDEABI-NZQKXSOJSA-NSMILESNC1=NC(O[C@H](C2=CC=C(Cl)C=C2C2=CC=CC=C2)C(F)(F)F)=CC(=N1)N1CCC2(CN[C@@H](C2)C(O)=O)CC1

Targets

What you can answer from here — as of July 09, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with Rodatristat, and which of those have an active Phase 3 trial?

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