JAK4D

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DB18527ExperimentalSmall molecule

JAK4D is a first-in-class thyrotropin-releasing hormone (TRH)-based compound.

Mechanism: Pharmacologically active on Thyrotropin-releasing hormone receptor
Curator reviewed
Formula / weight: C₃₄H₄₀N₈O₈ · 688.742 g/mol (avg)
Also known as: 5-oxo-l-prolyl-l-asparaginyl-l-prolyl-d-tyrosyl-d-tryptophanamide · L-pyroglutamyl-l-asparaginyl-l-prolyl-d-tyrosyl-d-tryptophan amide
Code names: JAK4D

Resolves to

Compound

UNIIAVX7AUJ938CAS882400-49-9

Structure

InChIKeySZQSOKVXBMULDL-VQHLWIOESA-NSMILESNC(=O)C[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CNC2=CC=CC=C12)C(N)=O

Targets

P34981TRHR

What you can answer from here — as of July 09, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with JAK4D, and which of those have an active Phase 3 trial?

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