PARPI F-18
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Identification
- Generic Name
- PARPI F-18
- DrugBank Accession Number
- DB18657
- Background
PARPI F-18 is a diagnostic agent under investigation for use in the management of glioblastoma multiforme.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 487.497
Monoisotopic: 487.168531414 - Chemical Formula
- C27H22F2N4O3
- Synonyms
- (18F)PARPI
- 1(2h)-phthalazinone, 4-((4-fluoro-3-((4-(4-(fluoro-18f)benzoyl)-1-piperazinyl)carbonyl)phenyl)methyl)-
- External IDs
- PARPI F 18
- PARPI F18
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- FT8GT4M7UG
- CAS number
- 1883580-48-0
- InChI Key
- LTZZZXXIKHHTMO-GLOFJIOZSA-N
- InChI
- InChI=1S/C27H22F2N4O3/c28-19-8-6-18(7-9-19)26(35)32-11-13-33(14-12-32)27(36)22-15-17(5-10-23(22)29)16-24-20-3-1-2-4-21(20)25(34)31-30-24/h1-10,15H,11-14,16H2,(H,31,34)/i28-1
- IUPAC Name
- 4-[(4-fluoro-3-{4-[4-(18F)fluorobenzoyl]piperazine-1-carbonyl}phenyl)methyl]-1,2-dihydrophthalazin-1-one
- SMILES
- FC1=CC=C(CC2=NNC(=O)C3=CC=CC=C23)C=C1C(=O)N1CCN(CC1)C(=O)C1=CC=C([18F])C=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 81367279
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 3.18 Chemaxon pKa (Strongest Acidic) 9.96 Chemaxon pKa (Strongest Basic) 0.84 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 82.08 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 131.01 m3·mol-1 Chemaxon Polarizability 48.08 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at October 05, 2023 19:45 / Updated at October 06, 2023 23:49