Zotarolimus

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DB18761InvestigationalSmall molecule

Zotarolimus is an immunosuppressant under investigation for use in drug-eluting stents.

Mechanism: Pharmacologically active on Peptidyl-prolyl cis-trans isomerase FKBP1A
Curator reviewed
Formula / weight: C₅₂H₇₉N₅O₁₂ · 966.227 g/mol (avg)
Code names: ABT-578 · MDT-4107

Resolves to

Compound

UNIIH4GXR80IZECAS221877-54-9ChEMBLCHEMBL219410ChEBI135897

Structure

InChIKeyCGTADGCBEXYWNE-KZHLOQFISA-NSMILES

CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@@H]1N1C=NN=N1

Targets

P62942FKBP1AP42345MTOR

What you can answer from here — as of August 31, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

2Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Zotarolimus, and which of those have an active Phase 3 trial?

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