Peptidyl-prolyl cis-trans isomerase FKBP1A

BE0000695ProteinHumansFKBP1A

Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. It is acted on by 22 drugs in DrugBank.

Gene name
FKBP1A
UniProtKB entry
P62942Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
108 residues · 11,951 Da
Also known as
12 kDa FK506-binding protein · 12 kDa FKBP · 5.2.1.8 · Calstabin-1 · FK506-binding protein 1A

Resolves to

Protein
UniProtP62942UniProt nameFKB1A_HUMAN
Gene
HGNCHGNC:3711NCBI Gene2280GenBank182628GeneCardsFKBP1A
Pharmacology
IUPHAR/GtoPdb2609KEGGhsa:2280
Structure
PDB1A7XPDB1B6CPDB1BKF
Drugs

What you can answer from here — as of September 07, 2019

22DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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63+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peptidyl-prolyl cis-trans isomerase FKBP1A, how selective are they, and which programs against it are still in active trials?

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