Serine/threonine-protein kinase mTOR

BE0002386ProteinHumansMTOR

Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (PubMed:12087098, PubMed:12150925, PubMed:12150926, PubMed:12231510, PubMed:12718876, PubMed:14651849, PubMed:15268862, PubMed:15467718, PubMed:15545625, PubMed:15718470,... It is acted on by 46 drugs in DrugBank.

Gene name
MTOR
UniProtKB entry
P42345Swiss-Prot
Cellular location
Lysosome membrane
Residues / weight
2,549 residues · 288,889 Da
Also known as
2.7.11.1 · FK506-binding protein 12-rapamycin complex-associated protein 1 · FKBP12-rapamycin complex-associated protein · FRAP · FRAP1

Resolves to

Protein
UniProtP42345UniProt nameMTOR_HUMAN
Gene
HGNCHGNC:3942NCBI Gene2475GeneCardsMTOR
Pharmacology
IUPHAR/GtoPdb2109KEGGhsa:2475
Structure
PDB1AUEPDB1FAPPDB1NSG
Drugs

What you can answer from here — as of September 07, 2019

46DrugsApproved to experimental, with action, bond type and pharmacological action
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164Clinical trialsTrials of drugs acting on it, by phase and status
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64GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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199+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase mTOR, how selective are they, and which programs against it are still in active trials?

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