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Navafenterol

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

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Identification

Generic Name
Navafenterol
DrugBank Accession Number
DB19195
Background

Navafenterol is under investigation in clinical trial NCT02971293 (Efficacy, Pharmacokinetics (PK), Safety and Tolerability Study of Inhaled AZD8871).

Type
Small Molecule
Groups
Investigational
Structure
Similar Structures
Weight
Average: 742.91
Monoisotopic: 742.260725444
Chemical Formula
C38H42N6O6S2
Synonyms
  • 2-thiopheneacetic acid, .alpha.-hydroxy-.alpha.-2-thienyl-, trans-4-((3-(5-((((2r)-2-(1,2-dihydro-8-hydroxy-2-oxo-5-quinolinyl)-2-hydroxyethyl)amino)methyl)-1h-benzotriazol-1-yl)propyl)methylamino)cyclohexyl ester
  • Trans-4-((3-(5-((((2r)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro-5- quinolinyl)ethyl)amino)methyl)-1h-benzotriazol-1-yl)propyl)(methyl)amino)cyclohexyl hydroxy(di-2-thienyl)acetate
External IDs
  • AZD 8871
  • AZD-8871
  • AZD8871
  • LAS 191351
  • LAS-191351
  • LAS191351
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
U29GY32XJ4
CAS number
1435519-06-4
InChI Key
ZNKWRAKPQQZLNX-ZDQHWEPJSA-N
InChI
InChI=1S/C38H42N6O6S2/c1-43(25-8-10-26(11-9-25)50-37(48)38(49,33-5-2-19-51-33)34-6-3-20-52-34)17-4-18-44-30-14-7-24(21-29(30)41-42-44)22-39-23-32(46)27-12-15-31(45)36-28(27)13-16-35(47)40-36/h2-3,5-7,12-16,19-21,25-26,32,39,45-46,49H,4,8-11,17-18,22-23H2,1H3,(H,40,47)/t25-,26-,32-/m0/s1
IUPAC Name
SMILES
CN(CCCN1N=NC2=CC(CNC[C@H](O)C3=C4C=CC(=O)NC4=C(O)C=C3)=CC=C12)[C@H]1CC[C@@H](CC1)OC(=O)C(O)(C1=CC=CS1)C1=CC=CS1

References

General References
Not Available
ChemSpider
81368421
BindingDB
50528210
ChEMBL
CHEMBL4297483
Wikipedia
Navafenterol

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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2CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)2somestatusstop reasonjust information to hide
1CompletedTreatmentAsthma (Part 1) / COPD (Part 2)1somestatusstop reasonjust information to hide
1CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)2somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at July 08, 2024 18:41 / Updated at July 10, 2024 02:16