Muscarinic acetylcholine receptor M3

BE0000045ProteinHumansCHRM3

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. It is acted on by 100 drugs in DrugBank.

Gene name
CHRM3
UniProtKB entry
P20309Swiss-Prot
Cellular location
Cell membrane
Residues / weight
590 residues · 66,127 Da

Resolves to

Protein
UniProtP20309UniProt nameACM3_HUMAN
Gene
HGNCHGNC:1952NCBI Gene1131GenBank32324GeneCardsCHRM3
Pharmacology
IUPHAR/GtoPdb15KEGGhsa:1131
Structure
PDB2CSAPDB8E9WPDB8E9Y
Drugs

What you can answer from here — as of September 07, 2019

100DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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317+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Muscarinic acetylcholine receptor M3, how selective are they, and which programs against it are still in active trials?

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