THK-5351

DB19222InvestigationalSmall molecule

THK-5351: Overview.

Mechanism: Pharmacologically active on Amine oxidase [flavin-containing] B and Microtubule-associated protein tau
Curator reviewed
Formula / weight: C₁₈H₁₈FN₃O₂ · 327.359 g/mol (avg)
Also known as: 2-(6-methylaminopyridine-3-yl)-6-((s)-3-fluoro-2-hydroxy-propyloxy)quinoline · 2-propanol, 1-fluoro-3-((2-(6-(methylamino)-3-pyridinyl)-6-quinolinyl)oxy)-, (2s)-
Code names: J3.349.111E · THK-5351

Resolves to

Compound

Structure

InChIKeyDLVXFZWSPCOWSN-CQSZACIVSA-NSMILESCNC1=CC=C(C=N1)C1=NC2=CC=C(OC[C@H](O)CF)C=C2C=C1

Targets

What you can answer from here — as of July 09, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

9Clinical trialsPhase, status and sponsor resolved per trial

8+ReferencesStructured and connected to the statements they support

Which drugs share a target with THK-5351, and which of those have an active Phase 3 trial?

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