Amine oxidase [flavin-containing] B

BE0002196ProteinHumansMAOB

Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the... It is acted on by 87 drugs in DrugBank.

Gene name
MAOB
UniProtKB entry
P27338Swiss-Prot
Cellular location
Mitochondrion outer membrane
Residues / weight
520 residues · 58,762 Da
Also known as
1.4.3.21 · 1.4.3.4 · MAO-B · Monoamine oxidase type B

Resolves to

Protein
UniProtP27338UniProt nameAOFB_HUMAN
Gene
HGNCHGNC:6834NCBI Gene4129GenBank398415GeneCardsMAOB
Pharmacology
IUPHAR/GtoPdb2490KEGGhsa:4129
Structure
PDB1GOSPDB1OJ9PDB1OJA
Drugs

What you can answer from here — as of September 07, 2019

87DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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9Metabolic reactionsDrug transformations it catalyses, substrate to product
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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264+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Amine oxidase [flavin-containing] B, how selective are they, and which programs against it are still in active trials?

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