Fuzapladib

DB19478ExperimentalSmall molecule

Fuzapladib is a small molecule drug. The usage of the INN stem '-pladib' in the name indicates that Fuzapladib is a phospholipase A2 inhibitor. Fuzapladib has a monoisotopic molecular weight...

Mechanism: Pharmacologically active on Cytosolic phospholipase A2 and Phospholipase A2
Curator reviewed
Formula / weight: C₁₅H₂₀F₃N₃O₃S · 379.4 g/mol (avg)
Code names: IS-741

Resolves to

Compound

UNII03TE67E8IRCAS141283-87-6

Clinical / RWD

RxNorm2632642

Structure

InChIKeyTUWCZRFHNIOVTC-UHFFFAOYSA-NSMILESCCS(=O)(=O)NC1=C(NC(=O)C2CCCCC2)C=C(C=N1)C(F)(F)F

Targets

P47712PLA2G4AP04054PLA2G1B

What you can answer from here — as of August 31, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with Fuzapladib, and which of those have an active Phase 3 trial?

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