Phospholipase A2

BE0003997ProteinHumansPLA2G1B

Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed:10681567, PubMed:1420353, PubMed:17603006). It is acted on by 40 drugs in DrugBank.

Gene name
PLA2G1B
UniProtKB entry
P04054Swiss-Prot
Cellular location
Secreted
Residues / weight
148 residues · 16,360 Da
Also known as
3.1.1.4 · Group IB phospholipase A2 · Phosphatidylcholine 2-acylhydrolase 1B · PLA2 · PLA2A

Resolves to

Protein
UniProtP04054UniProt namePA21B_HUMAN
Gene
HGNCHGNC:9030NCBI Gene5319GenBank190013GeneCardsPLA2G1B
Pharmacology
IUPHAR/GtoPdb1416KEGGhsa:5319
Structure
PDB3ELOPDB6Q42
Drugs

What you can answer from here — as of September 07, 2019

40DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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21GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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77+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phospholipase A2, how selective are they, and which programs against it are still in active trials?

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