Activin receptor type-1

BE0000264ProteinHumansACVR1

Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation (PubMed:20628059, PubMed:22977237). It is acted on by 12 drugs in DrugBank.

Gene name
ACVR1
UniProtKB entry
Q04771Swiss-Prot
Cellular location
Membrane
Residues / weight
509 residues · 57,152 Da
Also known as
2.7.11.30 · Activin receptor type I · Activin receptor-like kinase 2 · ACTR-I · ACVRLK2

Resolves to

Protein
UniProtQ04771UniProt nameACVR1_HUMAN
Gene
HGNCHGNC:171NCBI Gene90GenBank338219GeneCardsACVR1
Pharmacology
IUPHAR/GtoPdb1785KEGGhsa:90
Structure
PDB3H9RPDB3MTFPDB3OOM
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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34+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Activin receptor type-1, how selective are they, and which programs against it are still in active trials?

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