Tyrosine-protein phosphatase non-receptor type 1

BE0000623ProteinHumansPTPN1

Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. It is acted on by 69 drugs in DrugBank.

Gene name
PTPN1
UniProtKB entry
P18031Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
435 residues · 49,966 Da
Also known as
3.1.3.48 · Protein-tyrosine phosphatase 1B · PTP-1B · PTP1B

Resolves to

Protein
UniProtP18031UniProt namePTN1_HUMAN
Gene
HGNCHGNC:9642NCBI Gene5770GenBank190742GeneCardsPTPN1
Pharmacology
IUPHAR/GtoPdb2976KEGGhsa:5770
Structure
PDB1A5YPDB1AAXPDB1BZC
Drugs

What you can answer from here — as of September 07, 2019

69DrugsApproved to experimental, with action, bond type and pharmacological action
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29GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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181+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein phosphatase non-receptor type 1, how selective are they, and which programs against it are still in active trials?

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