Lacutoclax

DB21657InvestigationalSmall molecule

Lacutoclax is a small molecule drug. The usage of the INN stem '-toclax' in the name indicates that Lacutoclax is a B-cell lymphoma 2 (Bcl-2) inhibitor. Lacutoclax has a monoisotopic...

Mechanism: Pharmacologically active on Apoptosis regulator Bcl-2
Curator reviewed
Formula / weight: C₄₈H₅₅ClN₈O₇S · 923.53 g/mol (avg)

Resolves to

Compound

UNIIPMG5245L91CAS2291166-56-6ChEMBLCHEMBL5314523ChEBI759227PubChem153515493

Structure

InChIKeyCCDRQWAEZGRMTP-WJOKGBTCSA-NSMILES

C[C@@H]1CN(C2=CC(=CC=C2C(=O)NS(=O)(=O)C2=CC(=C(NCC3CCOCC3)C=C2)[N+]([O-])=O)N2CCN(CC3=C(CC(C)(C)CC3)C3=CC=C(Cl)C=C3)CC2)C2=C(O1)N=C1NC=CC1=C2

Targets

P10415BCL2Q92843BCL2L2Q07817BCL2L1

What you can answer from here — as of September 23, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

2Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Lacutoclax, and which of those have an active Phase 3 trial?

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