Prazosin hydrochlorideProduct ingredient for Prazosin
- Name
- Prazosin hydrochloride
- Drug Entry
- Prazosin
Prazosin is a drug used to treat hypertension. Prazosin is marketed by Pfizer and was initially approved by the FDA in 1988.16 It belongs to the class of drugs known as alpha-1 antagonists.
Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTSD) and associated nightmares.4,5,6
- Accession Number
- DBSALT000329
- Structure
- Synonyms
- Prazosin HCl
- UNII
- X0Z7454B90
- CAS Number
- 19237-84-4
- Weight
- Average: 419.862
Monoisotopic: 419.136031924 - Chemical Formula
- C19H22ClN5O4
- InChI Key
- WFXFYZULCQKPIP-UHFFFAOYSA-N
- InChI
- InChI=1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
- IUPAC Name
- 2-[4-(furan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxy-3,4-dihydroquinazolin-4-imine hydrochloride
- SMILES
- Cl.COC1=C(OC)C=C2C(=N)NC(=NC2=C1)N1CCN(CC1)C(=O)C1=CC=CO1
- External Links
- PubChem Compound
- 68546
- ChemSpider
- 61820
- ChEBI
- 8365
- ChEMBL
- CHEMBL1558
- Wikipedia
- Prazosin
- Predicted Properties
Property Value Source Water Solubility 0.456 mg/mL ALOGPS logP 1.21 ALOGPS logP 0.52 Chemaxon logS -2.9 ALOGPS pKa (Strongest Acidic) 11.09 Chemaxon pKa (Strongest Basic) 13.32 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 103.39 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 115.04 m3·mol-1 Chemaxon Polarizability 40.26 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon