Trazodone hydrochlorideProduct ingredient for Trazodone
- Name
- Trazodone hydrochloride
- Drug Entry
- Trazodone
Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants.11 It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine receptor inhibitor (SNRIs) in the treatment of depression.20 A unique feature of this drug is that it does not promote the anxiety symptoms, sexual symptoms, or insomnia, which are commonly associated with SSRI and SNRI therapy.20 Trazodone acts on various receptors, including certain histamine, serotonin, and adrenergic receptors, distinguishing it from other antidepressants that cover a narrow range of neurotransmitters.20 It was initially granted FDA approval in 1981.21
- Accession Number
- DBSALT000344
- Structure
- Synonyms
- Trazodone HCl
- UNII
- 6E8ZO8LRNM
- CAS Number
- 25332-39-2
- Weight
- Average: 408.325
Monoisotopic: 407.127965797 - Chemical Formula
- C19H23Cl2N5O
- InChI Key
- OHHDIOKRWWOXMT-UHFFFAOYSA-N
- InChI
- InChI=1S/C19H22ClN5O.ClH/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25;/h1-3,5-7,9,15H,4,8,10-14H2;1H
- IUPAC Name
- 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one hydrochloride
- SMILES
- Cl.ClC1=CC(=CC=C1)N1CCN(CCCN2N=C3C=CC=CN3C2=O)CC1
- External Links
- PubChem Compound
- 62935
- ChemSpider
- 56652
- ChEBI
- 9655
- ChEMBL
- CHEMBL1200798
- Wikipedia
- Trazodone
- Predicted Properties
Property Value Source Water Solubility 0.29 mg/mL ALOGPS logP 2.68 ALOGPS logP 3.13 Chemaxon logS -3.1 ALOGPS pKa (Strongest Basic) 7.09 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 42.39 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 105.88 m3·mol-1 Chemaxon Polarizability 40.28 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon