Clonidine hydrochlorideProduct ingredient for Clonidine
- Name
- Clonidine hydrochloride
- Drug Entry
- Clonidine
Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.2 This activity is useful for the treatment of hypertension, severe pain, and ADHD.8,9,10,11
Clonidine was granted FDA approval on 3 September 1974.8
- Accession Number
- DBSALT000538
- Structure
- Synonyms
- Clonidine HCl
- UNII
- W76I6XXF06
- CAS Number
- 4205-91-8
- Weight
- Average: 266.555
Monoisotopic: 264.994030456 - Chemical Formula
- C9H10Cl3N3
- InChI Key
- ZNIFSRGNXRYGHF-UHFFFAOYSA-N
- InChI
- InChI=1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H
- IUPAC Name
- N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride
- SMILES
- Cl.ClC1=CC=CC(Cl)=C1NC1=NCCN1
- External Links
- Predicted Properties
Property Value Source Water Solubility 0.48 mg/mL ALOGPS logP 2.55 ALOGPS logP 2.49 Chemaxon logS -2.7 ALOGPS pKa (Strongest Basic) 8.16 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 36.42 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 59.09 m3·mol-1 Chemaxon Polarizability 21.7 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon