Tetrahydropalmatine HydrochlorideProduct ingredient for Tetrahydropalmatine
- Name
- Tetrahydropalmatine Hydrochloride
- Drug Entry
- Tetrahydropalmatine
Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity).
- Accession Number
- DBSALT002133
- Structure
- Synonyms
- Not Available
- UNII
- RH72T8K75E
- CAS Number
- 4880-82-4
- Weight
- Average: 391.89
Monoisotopic: 391.155036 - Chemical Formula
- C21H26ClNO4
- InChI Key
- MGSZZQQRTPWMEI-LMOVPXPDSA-N
- InChI
- InChI=1S/C21H25NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,10-11,17H,7-9,12H2,1-4H3;1H/t17-;/m0./s1
- IUPAC Name
- (12bS)-3,4,10,11-tetramethoxy-7,8,12b,13-tetrahydro-5H-6-azatetraphene hydrochloride
- SMILES
- Cl.COC1=CC=C2C[C@@H]3N(CCC4=CC(OC)=C(OC)C=C34)CC2=C1OC
- External Links
- ChemSpider
- 4508543
- ChEMBL
- CHEMBL1359254
- Predicted Properties
Property Value Source Water Solubility 0.0246 mg/mL ALOGPS logP 3.09 ALOGPS logP 3.15 Chemaxon logS -4.2 ALOGPS pKa (Strongest Basic) 5.34 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 40.16 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 101.36 m3·mol-1 Chemaxon Polarizability 39.41 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon