Propiverine hydrochlorideProduct ingredient for Propiverine
- Name
- Propiverine hydrochloride
- Drug Entry
- Propiverine
Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB) 1.
Overactive bladder (OAB) is a chronic condition of the lower urinary tract characterized by urinary urgency, increased frequency of urination, and nocturia (frequent waking during the night to urinate). OAB has a negative impact on quality of life and may lead to leakage and inconvenient urinary accidents 15, 16. Overactive bladder syndrome affects millions of elderly individuals in the United States and shows equal prevalence in men and women. The impact of OAB on quality of life is sometimes devastating, especially to elderly patients with other medical conditions 16.
Propiverine hydrochloride is a bladder detrusor muscle relaxant drug with dual antimuscarinic and calcium-modulating properties for the treatment of OAB 7.
- Accession Number
- DBSALT002169
- Structure
- Synonyms
- Propiverine HCl
- UNII
- DC4GZD10H3
- CAS Number
- 54556-98-8
- Weight
- Average: 403.95
Monoisotopic: 403.1914215 - Chemical Formula
- C23H30ClNO3
- InChI Key
- KFUJMHHNLGCTIJ-UHFFFAOYSA-N
- InChI
- InChI=1S/C23H29NO3.ClH/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21;/h4-13,21H,3,14-18H2,1-2H3;1H
- IUPAC Name
- 1-methylpiperidin-4-yl 2,2-diphenyl-2-propoxyacetate hydrochloride
- SMILES
- Cl.CCCOC(C(=O)OC1CCN(C)CC1)(C1=CC=CC=C1)C1=CC=CC=C1
- External Links
- KEGG Drug
- D01007
- ChemSpider
- 37537
- ChEBI
- 8494
- ChEMBL
- CHEMBL2359059
- Predicted Properties
Property Value Source Water Solubility 0.00635 mg/mL ALOGPS logP 4.16 ALOGPS logP 4.25 Chemaxon logS -4.8 ALOGPS pKa (Strongest Basic) 8.72 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 38.77 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 107.73 m3·mol-1 Chemaxon Polarizability 41.88 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon