Glycopyrronium tosylateProduct ingredient for Glycopyrronium

Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers.¹⁵ They are both quaternary ammonium compounds and long acting muscarinic antagonists.¹⁵ It is one of the most commonly prescribed anticholinergic medications.^2,3 Early research into glycopyrronium use was for its indication as an adjunct therapy in the treatment of peptic ulcers.^9,10 Later research, taking advantage of the systemic distribution of muscarinic receptors through the body, found that glycopyrronium could also be used for reducing sweat gland,¹² oral,¹⁸ airway, and gastric secretions;¹⁷ as well as reducing cardiac inhibitory reflexes;¹⁷ and reducing bronchoconstriction in COPD.¹³ Glycopyrronium is commonly prescribed as a first line treatment for a wide variety indications and is considered to have a wider therapeutic window than tiotropium.⁸

Glycopyrronium was originally granted FDA approval on 11 August 1961.¹⁰