Tiotropium

DB01409ApprovedInvestigationalSmall moleculeAnticholinergic AgentsAntimuscarinics Antispasmodics

Tiotropium is a long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.

Chemical structure of Tiotropium
Mechanism
Curator reviewed · 10 references
Primary indication
Tiotropium powder for inhalation is indicated for the maintenance of bronchospasm in COPD and to prevent exacerbations of COPD.Curator reviewed · 23 structured indications
Formula / weight
C19H22NO4S2 · 392.512 g/mol (avg)
First approval
Canada, 2002 · United States, 2004
Code names
BA-679 BR
Brand names
  • Inspiolto Respimat
  • Spiriva
  • Spiriva Respimat
  • Stiolto

Resolves to

Compound
UNII0EB439235FCAS186691-13-4ChEMBLCHEMBL1900528ChEBI90960PubChem5487427
Clinical / RWD
RxNorm69120ATCR03AL06ATCR03AL10ATCR03BB04PharmGKBPA164769056
Structure
InChIKeyLERNTVKEWCAPOY-DZZGSBJMSA-NSMILES[H][C@]12O[C@@]1([H])[C@]1([H])C[C@@]([H])(C[C@@]2([H])[N+]1(C)C)OC(=O)C(O)(C1=CC=CS1)C1=CC=CS1
Targets
P20309CHRM3P11229CHRM1P08172CHRM2P08173CHRM4P08912CHRM5
Transporters
O76082SLC22A5Q9H015SLC22A4

What you can answer from here — as of September 29, 2026

5Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
2TransportersSubstrate / inhibitor direction, not just membership
Listed above
1,426Drug interactionsStructured to mechanism, not free text
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89Clinical trialsPhase, status and sponsor resolved per trial
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23Structured indicationsCondition, population, route and combination as fields, not prose
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2ContraindicationsEach with its own population and attribute set
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167Marketed productsAcross 10 countries and 33 labellers
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4ATC codesIncluding every combination product, plus 25 drug categories
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23+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Tiotropium, and which of those have an active Phase 3 trial?

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