Moxonidine hydrochlorideProduct ingredient for Moxonidine
- Name
- Moxonidine hydrochloride
- Drug Entry
- Moxonidine
Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or irresponsive. As well, moxonidine has been shown to present blood pressure-independent beneficial effects on insulin resistance syndrome.
- Accession Number
- DBSALT002876
- Structure
- Synonyms
- Moxonidine HCl
- UNII
- 5RYW07SK5E
- CAS Number
- 75438-58-3
- Weight
- Average: 278.14
Monoisotopic: 277.0497155 - Chemical Formula
- C9H13Cl2N5O
- InChI Key
- ZZPAWQYZQVUVHX-UHFFFAOYSA-N
- InChI
- InChI=1S/C9H12ClN5O.ClH/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9;/h3-4H2,1-2H3,(H2,11,12,15);1H
- IUPAC Name
- 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine hydrochloride
- SMILES
- Cl.COC1=NC(C)=NC(Cl)=C1NC1=NCCN1
- External Links
- ChemSpider
- 9406303
- ChEMBL
- CHEMBL1256287
- Predicted Properties
Property Value Source Water Solubility 0.114 mg/mL ALOGPS logP 1.01 ALOGPS logP 1.54 Chemaxon logS -3.3 ALOGPS pKa (Strongest Basic) 7.26 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 71.43 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 63.41 m3·mol-1 Chemaxon Polarizability 23.57 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon