Metastatic Urothelial Cancer

DrugDrug NameDrug Description
DB11945AvelumabAn anti-PD-L1 monoclonal antibody used to treat metastatic merkel cell carcinoma, metastatic urothelial carcinoma, or renal cell carcinoma.
DB00997DoxorubicinA medication used to treat various cancers, including AIDS-associated Kaposi's Sarcoma and metastatic cancers.
DB13007Enfortumab vedotinAn antibody-drug conjugate comprised of a fully human monoclonal antibody and microtubule-disrupting chemotherapeutic agent used in the treatment of advanced or metastatic urothelial cancer.
DrugDrug NameTargetType
DB11945AvelumabProgrammed cell death 1 ligand 1target
DB00997DoxorubicinDNA topoisomerase 2-alphatarget
DB00997DoxorubicinDNAtarget
DB00997DoxorubicinCytochrome P450 3A4enzyme
DB00997DoxorubicinCytochrome P450 2D6enzyme
DB00997DoxorubicinCytochrome P450 2B6enzyme
DB00997DoxorubicinP-glycoprotein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 2transporter
DB00997DoxorubicinMultidrug resistance-associated protein 6transporter
DB00997DoxorubicinMultidrug resistance-associated protein 1transporter
DB00997DoxorubicinMultidrug resistance-associated protein 7transporter
DB00997DoxorubicinATP-binding cassette sub-family G member 2transporter
DB00997DoxorubicinBile salt export pumptransporter
DB00997DoxorubicinSolute carrier family 22 member 16transporter
DB00997DoxorubicinATP-binding cassette sub-family B member 8, mitochondrialtransporter
DB00997DoxorubicinCytochrome P450 1B1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 3enzyme
DB00997DoxorubicinAlcohol dehydrogenase [NADP(+)]enzyme
DB00997DoxorubicinAldo-keto reductase family 1 member C3enzyme
DB00997DoxorubicinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00997DoxorubicinXanthine dehydrogenase/oxidaseenzyme
DB00997DoxorubicinNitric oxide synthase, endothelialenzyme
DB00997DoxorubicinNitric oxide synthase, inducibleenzyme
DB00997DoxorubicinNitric oxide synthase, brainenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialenzyme
DB00997DoxorubicinNADPH--cytochrome P450 reductaseenzyme
DB00997DoxorubicinRalA-binding protein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 1transporter
DB00997DoxorubicinSerum albumincarrier
DB00997DoxorubicinNucleolar and coiled-body phosphoprotein 1target
DB00997DoxorubicinDNA topoisomerase 1target
DB00997DoxorubicinDNA topoisomerase 2-betatarget
DB00997DoxorubicinAldose reductaseenzyme
DB00997DoxorubicinAldo-keto reductase family 1 member B10enzyme
DB00997DoxorubicinAldo-keto reductase family 1 member C4enzyme
DB13007Enfortumab vedotinCytochrome P450 3A4enzyme
DB13007Enfortumab vedotinNectin-4target
DB13007Enfortumab vedotinP-glycoprotein 1transporter
DrugDrug NamePhaseStatusCount
DB13007Enfortumab vedotin1Completed1
DB09037Pembrolizumab1Completed1
DB12893Sacituzumab govitecan1 / 2Recruiting1
DB11945Avelumab2Active Not Recruiting1
DB11945Avelumab2Recruiting1
DB00958Carboplatin2Active Not Recruiting2
DB00958Carboplatin2Recruiting1
DB00515Cisplatin2Recruiting1
DB13007Enfortumab vedotin2Active Not Recruiting1
DB00441Gemcitabine2Active Not Recruiting2
DB00441Gemcitabine2Recruiting1
DB09035Nivolumab2Active Not Recruiting1
DB09074Olaparib2Active Not Recruiting1
DB00526Oxaliplatin2Active Not Recruiting1
DB01229Paclitaxel2Unknown Status1
DB09037Pembrolizumab2Recruiting1
DB15766Retifanlimab2Completed1
DB12893Sacituzumab govitecan2Recruiting1
DB11836Sapanisertib2Unknown Status1
DB17505Zimberelimab2Recruiting1
DB00958Carboplatin2 / 3Completed1
DB00515Cisplatin2 / 3Completed1
DB00441Gemcitabine2 / 3Completed1
DB00958Carboplatin3Recruiting1
DB00515Cisplatin3Recruiting1
DB11714Durvalumab3Recruiting1
DB00441Gemcitabine3Recruiting1
DB11771Tremelimumab3Recruiting1