L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase

Details

Name

L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase

Synonyms

• 6.3.1.13
• L-Cys:GlcN-Ins ligase
• MSH ligase
• Mycothiol ligase

Gene Name

mshC

Organism

Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)

Amino acid sequence

>lcl|BSEQ0052786|L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
MQSWYCPPVPVLPGRGPQLRLYDSADRQVRPVAPGSKATMYVCGITPYDATHLGHAATYV
TFDLIHRLWLDLGHELHYVQNITDIDDPLFERADRDGVDWRDLAQAEVALFCEDMAALRV
LPPQDYVGATEAIAEMVELIEKMLACGAAYVIDREMGEYQDIYFRADATLQFGYESGYDR
DTMLRLCEERGGDPRRPGKSDELDALLWRAARPGEPSWPSPFGPGRPGWHVECAAIALSR
IGSGLDIQGGGSDLIFPHHEFTAAHAECVSGERRFARHYVHAGMIGWDGHKMSKSRGNLV
LVSALRAQDVEPSAVRLGLLAGHYRADRFWSQQVLDEATARLHRWRTATALPAGPAAVDV
VARVRRYLADDLDTPKAIAALDGWVTDAVEYGGHDAGAPKLVATAIDALLGVDL

Number of residues

414

Molecular Weight

45594.045

Theoretical pI

Not Available

GO Classification

Functions

ATP binding / cysteine-glucosaminylinositol ligase activity / zinc ion binding

Processes

mycothiol biosynthetic process

General Function

Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.

Specific Function

Atp binding

Pfam Domain Function

• tRNA-synt_1e (PF01406)

Transmembrane Regions

Not Available

Cellular Location

Not Available

Gene sequence

>lcl|BSEQ0052787|L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase (mshC)
ATGCAGTCGTGGTATTGCCCACCGGTTCCGGTGTTGCCGGGACGAGGCCCGCAGCTACGG
CTGTACGACAGCGCCGACCGGCAGGTCCGTCCGGTGGCGCCCGGATCTAAGGCCACCATG
TACGTCTGCGGGATCACGCCCTACGACGCCACGCATCTGGGCCATGCTGCCACCTATGTG
ACGTTCGACCTGATCCATCGGCTGTGGCTGGATCTCGGTCATGAATTGCACTATGTCCAG
AACATCACCGACATCGACGATCCACTATTTGAGCGCGCGGATCGCGACGGTGTCGACTGG
CGTGACCTTGCCCAAGCCGAGGTCGCCCTGTTCTGTGAGGACATGGCGGCGCTGCGGGTG
CTACCACCGCAAGACTACGTGGGGGCCACCGAAGCGATTGCTGAAATGGTCGAGCTCATC
GAAAAAATGCTGGCGTGCGGGGCGGCCTATGTCATAGACCGGGAAATGGGAGAGTACCAG
GACATCTACTTCCGCGCTGACGCCACCCTGCAGTTCGGCTACGAGTCAGGGTATGACCGT
GACACCATGCTGCGGCTGTGCGAGGAACGTGGCGGCGATCCGCGGCGCCCCGGCAAGAGC
GACGAACTCGACGCGTTGTTGTGGCGGGCCGCGCGGCCCGGTGAGCCCAGCTGGCCGTCC
CCGTTCGGGCCTGGCCGGCCAGGCTGGCATGTCGAGTGCGCAGCCATCGCGCTCAGTCGT
ATCGGAAGCGGCCTCGACATCCAGGGCGGTGGTAGCGATCTGATCTTTCCGCACCACGAG
TTCACCGCTGCGCACGCCGAATGTGTCAGCGGCGAACGGCGATTCGCGCGGCACTACGTG
CATGCCGGGATGATCGGCTGGGACGGGCACAAGATGTCAAAGAGCCGCGGCAACCTCGTG
CTGGTGTCGGCGCTGCGTGCGCAGGACGTTGAGCCATCGGCGGTTCGGCTGGGTTTGCTC
GCCGGACACTACCGAGCCGATCGGTTCTGGAGCCAGCAGGTGCTTGACGAGGCGACCGCC
CGGCTGCACCGTTGGCGCACCGCAACCGCACTTCCCGCCGGTCCGGCCGCAGTTGACGTT
GTCGCTCGGGTGCGCCGCTACCTGGCCGACGATCTCGATACGCCCAAAGCGATTGCCGCA
CTGGATGGTTGGGTCACCGATGCGGTGGAGTACGGCGGCCACGATGCCGGGGCGCCGAAG
TTGGTGGCGACGGCGATCGATGCCCTGCTCGGGGTGGACCTGTAG

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	A5U4F6
UniProtKB Entry Name	MSHC_MYCTA

General References

Not Available

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB04209	Dequalinium	approved, investigational	unknown	inhibitor	Details