Cytochrome P450 1A1
Details
- Name
- Cytochrome P450 1A1
- Synonyms
- 1.14.14.1
- Cyp1a-1
- CYP1A1
- CYPIA1
- Cytochrome P450-C
- Cytochrome P450MT2
- Gene Name
- Cyp1a1
- Organism
- Rat
- Amino acid sequence
>lcl|BSEQ0051627|Cytochrome P450 1A1 MPSVYGFPAFTSATELLLAVTTFCLGFWVVRVTRTWVPKGLKSPPGPWGLPFIGHVLTLG KNPHLSLTKLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVKQGDDFKGRPDLYSFTLIA NGQSMTFNPDSGPLWAARRRLAQNALKSFSIASDPTLASSCYLEEHVSKEAEYLISKFQK LMAEVGHFDPFKYLVVSVANVICAICFGRRYDHDDQELLSIVNLSNEFGEVTGSGYPADF IPILRYLPNSSLDAFKDLNKKFYSFMKKLIKEHYRTFEKGHIRDITDSLIEHCQDRRLDE NANVQLSDDKVITIVFDLFGAGFDTITTAISWSLMYLVTNPRIQRKIQEELDTVIGRDRQ PRLSDRPQLPYLEAFILETFRHSSFVPFTIPHSTIRDTSLNGFYIPKGHCVFVNQWQVNH DQELWGDPNEFRPERFLTSSGTLDKHLSEKVILFGLGKRKCIGETIGRLEVFLFLAILLQ QMEFNVSPGEKVDMTPAYGLTLKHARCEHFQVQMRSSGPQHLQA
- Number of residues
- 524
- Molecular Weight
- 59392.695
- Theoretical pI
- Not Available
- GO Classification
- Functionsaromatase activity / catalytic activity / demethylase activity / enzyme binding / estrogen 16-alpha-hydroxylase activity / flavonoid 3'-monooxygenase activity / heme binding / iron ion binding / monooxygenase activity / oxidoreductase activity / oxidoreductase activity, acting on diphenols and related substances as donors / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / steroid hydroxylase activity / vitamin D 24-hydroxylase activityProcesses9-cis-retinoic acid biosynthetic process / aging / amine metabolic process / camera-type eye development / cell proliferation / cellular response to copper ion / cellular response to organic cyclic compound / coumarin metabolic process / developmental process / dibenzo-p-dioxin catabolic process / dibenzo-p-dioxin metabolic process / digestive tract development / drug metabolic process / flavonoid metabolic process / hepatocyte differentiation / heterocycle metabolic process / hydrogen peroxide biosynthetic process / insecticide metabolic process / lipid hydroxylation / liver development / maternal process involved in parturition / oxidation-reduction process / porphyrin-containing compound metabolic process / positive regulation of G1/S transition of mitotic cell cycle / response to antibiotic / response to arsenic-containing substance / response to drug / response to food / response to herbicide / response to hyperoxia / response to hypoxia / response to immobilization stress / response to iron(III) ion / response to lipopolysaccharide / response to nematode / response to organic cyclic compound / response to organic substance / response to toxic substance / response to virus / response to vitamin A / response to wounding / steroid metabolic process / toxin metabolic processComponentscytoplasm / endoplasmic reticulum membrane / intracellular membrane-bounded organelle / mitochondrial membrane / mitochondrion
- General Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- Specific Function
- Aromatase activity
- Pfam Domain Function
- p450 (PF00067)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051628|Cytochrome P450 1A1 (Cyp1a1) ATGCCTTCTGTGTATGGATTCCCAGCCTTCACATCAGCCACAGAGCTGCTCTTGGCCGTC ACCACATTCTGCCTTGGATTCTGGGTGGTTAGAGTCACAAGAACCTGGGTTCCCAAAGGT CTGAAGAGTCCACCCGGACCCTGGGGCTTGCCCTTCATGGGGCACGTGCTGACCCTGGGG AAGAACCCACACCTGTCACTGACAAAACTGAGTCAGCAGTATGGGGACGTGCTGCAGATC CGTATTGGCTCCACACCCGTGGTGGTGCTGAGCGGCCTGAACACCATCAAGCAGGCCCTG GTGAAACAGGGGGATGACTTCAAAGGCCGGCCAGACCTCTACAGCTTCACACTTATCGCT AATGGCCAGAGCATGACTTTCAACCCAGACTCTGGACCGCTGTGGGCTGCCCGCCGGCGC CTGGCCCAGAATGCGCTGAAGAGTTTCTCCATAGCCTCAGACCCAACACTGGCATCCTCT TGCTACTTGGAAGAGCACGTGAGCAAAGAGGCTGAATACTTAATCAGCAAGTTCCAGAAG CTGATGGCAGAGGTTGGCCACTTCGACCCTTTCAAGTATTTGGTGGTGTCAGTGGCCAAT GTCATCTGTGCCATATGCTTTGGCAGACGTTATGACCACGATGACCAAGAGCTGCTCAGC ATAGTCAATCTAAGCAATGAGTTTGGGGAGGTTACTGGTTCTGGATACCCAGCTGACTTC ATTCCTATCCTCCGTTACCTCCCTAACTCTTCCCTGGATGCCTTCAAGGACTTGAATAAG AAGTTCTACAGTTTCATGAAGAAGCTAATCAAAGAGCACTACAGGACATTTGAGAAGGGC CACATCCGGGACATCACAGACAGCCTCATTGAGCATTGTCAGGACAGGAGGCTGGACGAG AATGCCAATGTCCAGCTCTCAGATGATAAGGTCATTACGATTGTTTTTGACCTCTTTGGA GCTGGGTTTGACACAATCACAACTGCTATCTCTTGGAGCCTCATGTACCTGGTAACCAAC CCTAGGATACAGAGAAAGATCCAGGAGGAGTTAGACACAGTGATTGGCAGGGATCGGCAG CCCCGGCTTTCTGACAGACCTCAGCTGCCCTATCTGGAGGCCTTCATCCTGGAGACCTTC CGACATTCATCCTTTGTCCCATTCACCATCCCCCACAGCACCATAAGAGATACAAGTCTG AATGGCTTCTATATCCCCAAGGGACACTGTGTCTTTGTGAACCAGTGGCAGGTTAACCAT GACCAGGAACTATGGGGTGATCCAAACGAGTTCCGGCCTGAAAGGTTTCTTACCTCCAGT GGCACTCTGGACAAACACCTGAGTGAGAAGGTCATTCTCTTTGGTTTGGGCAAGCGAAAG TGCATTGGGGAGACCATTGGCCGACTGGAGGTCTTTCTCTTCCTGGCCATCCTGCTGCAG CAAATGGAATTTAATGTGTCACCAGGCGAGAAGGTGGATATGACTCCTGCCTATGGGCTG ACTTTAAAACATGCCCGCTGTGAGCACTTCCAAGTGCAGATGCGGTCTTCTGGTCCTCAG CATCTCCAGGCTTAG
- Chromosome Location
- 8
- Locus
- 8q24
- External Identifiers
Resource Link UniProtKB ID P00185 UniProtKB Entry Name CP1A1_RAT - General References
- Sogawa K, Gotoh O, Kawajiri K, Fujii-Kuriyama Y: Distinct organization of methylcholanthrene- and phenobarbital-inducible cytochrome P-450 genes in the rat. Proc Natl Acad Sci U S A. 1984 Aug;81(16):5066-70. [Article]
- Yabusaki Y, Shimizu M, Murakami H, Nakamura K, Oeda K, Ohkawa H: Nucleotide sequence of a full-length cDNA coding for 3-methylcholanthrene-induced rat liver cytochrome P-450MC. Nucleic Acids Res. 1984 Mar 26;12(6):2929-38. [Article]
- Hines RN, Levy JB, Conrad RD, Iversen PL, Shen ML, Renli AM, Bresnick E: Gene structure and nucleotide sequence for rat cytochrome P-450c. Arch Biochem Biophys. 1985 Mar;237(2):465-76. [Article]
- Cheng KC, Park SS, Krutzsch HC, Grantham PH, Gelboin HV, Friedman FK: Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450. Biochemistry. 1986 May 6;25(9):2397-402. [Article]
- Amelizad Z, Narbonne JF, Wolf CR, Robertson LW, Oesch F: Effect of nutritional imbalances on cytochrome P-450 isozymes in rat liver. Biochem Pharmacol. 1988 Sep 1;37(17):3245-9. [Article]
- Cvrk T, Hodek P, Strobel HW: Identification and characterization of cytochrome P4501A1 amino acid residues interacting with a radiolabeled photoaffinity diazido-benzphetamine analogue. Arch Biochem Biophys. 1996 Jun 1;330(1):142-52. doi: 10.1006/abbi.1996.0236. [Article]
- Addya S, Anandatheerthavarada HK, Biswas G, Bhagwat SV, Mullick J, Avadhani NG: Targeting of NH2-terminal-processed microsomal protein to mitochondria: a novel pathway for the biogenesis of hepatic mitochondrial P450MT2. J Cell Biol. 1997 Nov 3;139(3):589-99. [Article]
- Cao W, Cao J, Huang J, Yao J, Yan G, Xu H, Yang P: Discovery and confirmation of O-GlcNAcylated proteins in rat liver mitochondria by combination of mass spectrometry and immunological methods. PLoS One. 2013 Oct 2;8(10):e76399. doi: 10.1371/journal.pone.0076399. eCollection 2013. [Article]